2bw3

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[[Image:2bw3.gif|left|200px]]
[[Image:2bw3.gif|left|200px]]
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{{Structure
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|PDB= 2bw3 |SIZE=350|CAPTION= <scene name='initialview01'>2bw3</scene>, resolution 2.00&Aring;
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The line below this paragraph, containing "STRUCTURE_2bw3", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
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{{STRUCTURE_2bw3| PDB=2bw3 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bw3 OCA], [http://www.ebi.ac.uk/pdbsum/2bw3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2bw3 RCSB]</span>
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'''THREE-DIMENSIONAL STRUCTURE OF THE HERMES DNA TRANSPOSASE'''
'''THREE-DIMENSIONAL STRUCTURE OF THE HERMES DNA TRANSPOSASE'''
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[[Category: Perez, Z N.]]
[[Category: Perez, Z N.]]
[[Category: Zhou, L.]]
[[Category: Zhou, L.]]
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[[Category: dna recombination]]
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[[Category: Dna recombination]]
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[[Category: transposition]]
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[[Category: Transposition]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:53:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:12:39 2008''
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Revision as of 17:53, 3 May 2008

Image:2bw3.gif

Template:STRUCTURE 2bw3

THREE-DIMENSIONAL STRUCTURE OF THE HERMES DNA TRANSPOSASE


Overview

Mobile elements and their inactive remnants account for large proportions of most eukaryotic genomes, where they have had central roles in genome evolution. Over 50 years ago, McClintock reported a form of stress-induced genome instability in maize in which discrete DNA segments move between chromosomal locations. Our current mechanistic understanding of enzymes catalyzing transposition is largely limited to prokaryotic transposases. The Hermes transposon from the housefly is part of the eukaryotic hAT superfamily that includes hobo from Drosophila, McClintock's maize Activator and Tam3 from snapdragon. We report here the three-dimensional structure of a functionally active form of the transposase from Hermes at 2.1-A resolution. The Hermes protein has some structural features of prokaryotic transposases, including a domain with a retroviral integrase fold. However, this domain is disrupted by the insertion of an additional domain. Finally, transposition is observed only when Hermes assembles into a hexamer.

About this Structure

2BW3 is a Protein complex structure of sequences from Musca domestica. Full crystallographic information is available from OCA.

Reference

Molecular architecture of a eukaryotic DNA transposase., Hickman AB, Perez ZN, Zhou L, Musingarimi P, Ghirlando R, Hinshaw JE, Craig NL, Dyda F, Nat Struct Mol Biol. 2005 Aug;12(8):715-21. Epub 2005 Jul 24. PMID:16041385 Page seeded by OCA on Sat May 3 20:53:03 2008

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