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2by4

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[[Image:2by4.gif|left|200px]]
[[Image:2by4.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2by4 |SIZE=350|CAPTION= <scene name='initialview01'>2by4</scene>, resolution 3.30&Aring;
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The line below this paragraph, containing "STRUCTURE_2by4", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Na+Binding+Site+For+Chain+A'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=AD4:(3S,3AR,4S,6S,6AR,7S,8S,9BS)-6-(ACETYLOXY)-3,3A-DIHYDROXY-3,6,9-TRIMETHYL-8-{[(2Z)-2-METHYLBUT-2-ENOYL]OXY}-7-(OCTANOYLOXY)-2-OXO-2,3,3A,4,5,6,6A,7,8,9B-DECAHYDROAZULENO[4,5-B]FURAN-4-YL+12-[(TERT-BUTOXYCARBONYL)AMINO]DODECANOATE'>AD4</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Calcium-transporting_ATPase Calcium-transporting ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.8 3.6.3.8] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2by4| PDB=2by4 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2by4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2by4 OCA], [http://www.ebi.ac.uk/pdbsum/2by4 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2by4 RCSB]</span>
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}}
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'''SR CA(2+)-ATPASE IN THE HNE2 STATE COMPLEXED WITH THE THAPSIGARGIN DERIVATIVE BOC-12ADT.'''
'''SR CA(2+)-ATPASE IN THE HNE2 STATE COMPLEXED WITH THE THAPSIGARGIN DERIVATIVE BOC-12ADT.'''
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[[Category: Olsen, C E.]]
[[Category: Olsen, C E.]]
[[Category: Soehoel, H.]]
[[Category: Soehoel, H.]]
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[[Category: atp-binding]]
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[[Category: Atp-binding]]
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[[Category: ca2+-atpase]]
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[[Category: Ca2+-atpase]]
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[[Category: calcium]]
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[[Category: Calcium]]
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[[Category: calcium transport]]
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[[Category: Calcium transport]]
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[[Category: endoplasmic reticulum]]
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[[Category: Endoplasmic reticulum]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: ion transport]]
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[[Category: Ion transport]]
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[[Category: magnesium]]
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[[Category: Magnesium]]
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[[Category: metal-binding]]
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[[Category: Metal-binding]]
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[[Category: multigene family]]
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[[Category: Multigene family]]
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[[Category: nucleotide-binding]]
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[[Category: Nucleotide-binding]]
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[[Category: p-type atpase]]
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[[Category: P-type atpase]]
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[[Category: phosphorylation]]
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[[Category: Phosphorylation]]
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[[Category: prostate cancer]]
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[[Category: Prostate cancer]]
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[[Category: sarcoplasmic reticulum,transmembrane]]
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[[Category: Sarcoplasmic reticulum,transmembrane]]
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[[Category: serca]]
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[[Category: Serca]]
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[[Category: thapsigargin]]
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[[Category: Thapsigargin]]
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[[Category: transport]]
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[[Category: Transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:57:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:13:28 2008''
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Revision as of 17:57, 3 May 2008

Image:2by4.gif

Template:STRUCTURE 2by4

SR CA(2+)-ATPASE IN THE HNE2 STATE COMPLEXED WITH THE THAPSIGARGIN DERIVATIVE BOC-12ADT.


Overview

An analysis of the binding of the 8-O-N-tert-butoxycarbonyl-12-aminododecanoyl derivative of 8-O-debutanoylthapsigargin to the target molecule, the SERCA pump, has revealed the importance of the length and flexibility of the side chain attached to O-8. Based on the analysis a series of analogues to the 2-unsubstituted analogue trilobolide has been constructed and shown to be equipotent with thapsigargin as SERCA inhibitors. Only the 12-Boc-aminododecaonoyl derivative, however, was found to be apoptotic.

About this Structure

2BY4 is a Single protein structure of sequence from Oryctolagus cuniculus. Full crystallographic information is available from OCA.

Reference

Natural products as starting materials for development of second-generation SERCA inhibitors targeted towards prostate cancer cells., Sohoel H, Jensen AM, Moller JV, Nissen P, Denmeade SR, Isaacs JT, Olsen CE, Christensen SB, Bioorg Med Chem. 2006 Apr 15;14(8):2810-5. Epub 2006 Jan 10. PMID:16412648 Page seeded by OCA on Sat May 3 20:57:30 2008

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