2byt

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2byt.gif|left|200px]]
[[Image:2byt.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2byt |SIZE=350|CAPTION= <scene name='initialview01'>2byt</scene>, resolution 3.30&Aring;
+
The line below this paragraph, containing "STRUCTURE_2byt", creates the "Structure Box" on the page.
-
|SITE= <scene name='pdbsite=AC1:Hg+Binding+Site+For+Chain+D'>AC1</scene>
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=LEU:LEUCINE'>LEU</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2byt| PDB=2byt | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2byt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2byt OCA], [http://www.ebi.ac.uk/pdbsum/2byt PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2byt RCSB]</span>
+
-
}}
+
'''THERMUS THERMOPHILUS LEUCYL-TRNA SYNTHETASE COMPLEXED WITH A TRNALEU TRANSCRIPT IN THE POST-EDITING CONFORMATION'''
'''THERMUS THERMOPHILUS LEUCYL-TRNA SYNTHETASE COMPLEXED WITH A TRNALEU TRANSCRIPT IN THE POST-EDITING CONFORMATION'''
Line 30: Line 27:
[[Category: Yaremchuk, A.]]
[[Category: Yaremchuk, A.]]
[[Category: Yokoyama, S.]]
[[Category: Yokoyama, S.]]
-
[[Category: aminoacyl-trna synthetase]]
+
[[Category: Aminoacyl-trna synthetase]]
-
[[Category: atp + l-leucine + trna (leu) gives amp + ppi l-leucyl-trna(leu)]]
+
[[Category: Class i aminoacyl-trna synthetase]]
-
[[Category: class i aminoacyl-trna synthetase]]
+
[[Category: Editing]]
-
[[Category: editing]]
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:59:12 2008''
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:13:47 2008''
+

Revision as of 17:59, 3 May 2008

Image:2byt.gif

Template:STRUCTURE 2byt

THERMUS THERMOPHILUS LEUCYL-TRNA SYNTHETASE COMPLEXED WITH A TRNALEU TRANSCRIPT IN THE POST-EDITING CONFORMATION


Overview

Leucyl-tRNA synthetase (LeuRS) has a specific post-transfer editing activity directed against mischarged isoleucine and similar noncognate amino acids. We describe the post-transfer-editing and product complexes of Thermus thermophilus LeuRS (LeuRSTT) with tRNA(Leu) at 2.9- to 3.3-A resolution. In the post-transfer-editing configuration, A76 binds in the editing active site exactly as previously found for the adenosine moiety of a small-molecule editing-substrate analog. The 60 C-terminal residues of LeuRSTT, unseen in previous structures, fold into a compact domain flexibly linked to the rest of the molecule and interacting with the G19-C56 tertiary base pair of tRNA(Leu). LeuRS recognition of tRNA(Leu) depends essentially on tRNA shape rather than base-specific interactions. The structures show that considerable domain rotations, notably of the editing domain, accompany the tRNA-3' end dynamics associated successively with aminoacylation, post-transfer editing and product release.

About this Structure

2BYT is a Protein complex structure of sequences from Thermus thermophilus. Full crystallographic information is available from OCA.

Reference

The crystal structure of leucyl-tRNA synthetase complexed with tRNALeu in the post-transfer-editing conformation., Tukalo M, Yaremchuk A, Fukunaga R, Yokoyama S, Cusack S, Nat Struct Mol Biol. 2005 Oct;12(10):923-30. Epub 2005 Sep 11. PMID:16155583 Page seeded by OCA on Sat May 3 20:59:12 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2byt"
Personal tools