2bz5

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[[Image:2bz5.gif|left|200px]]
[[Image:2bz5.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2bz5 |SIZE=350|CAPTION= <scene name='initialview01'>2bz5</scene>, resolution 1.90&Aring;
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The line below this paragraph, containing "STRUCTURE_2bz5", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Ab4+Binding+Site+For+Chain+B'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=AB4:2,5-DICHLORO-N-[4-HYDROXY-3-(2-HYDROXY-1-NAPHTHYL)PHENYL]BENZENESULFONAMIDE'>AB4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2bz5| PDB=2bz5 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bz5 OCA], [http://www.ebi.ac.uk/pdbsum/2bz5 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2bz5 RCSB]</span>
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}}
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'''STRUCTURE-BASED DISCOVERY OF A NEW CLASS OF HSP90 INHIBITORS'''
'''STRUCTURE-BASED DISCOVERY OF A NEW CLASS OF HSP90 INHIBITORS'''
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[[Category: Surgenor, A.]]
[[Category: Surgenor, A.]]
[[Category: Wright, L.]]
[[Category: Wright, L.]]
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[[Category: atp-binding]]
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[[Category: Atp-binding]]
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[[Category: chaperone]]
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[[Category: Chaperone]]
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[[Category: heat shock]]
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[[Category: Heat shock]]
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[[Category: nucleotide-binding]]
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[[Category: Nucleotide-binding]]
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[[Category: phosphorylation]]
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[[Category: Phosphorylation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 21:00:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:14:09 2008''
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Revision as of 18:00, 3 May 2008

Image:2bz5.gif

Template:STRUCTURE 2bz5

STRUCTURE-BASED DISCOVERY OF A NEW CLASS OF HSP90 INHIBITORS


Overview

Docking-based virtual screening identified 1-(2-phenol)-2-naphthol compounds as a new class of Hsp90 inhibitors of low to sub-micromolar potency. Here we report the binding affinities and cellular activities of several members of this class. A high resolution crystal structure of the most potent compound reveals its binding mode in the ATP binding site of Hsp90, providing a rationale for the observed activity of the series and suggesting strategies for developing compounds with improved properties.

About this Structure

2BZ5 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure-based discovery of a new class of Hsp90 inhibitors., Barril X, Brough P, Drysdale M, Hubbard RE, Massey A, Surgenor A, Wright L, Bioorg Med Chem Lett. 2005 Dec 1;15(23):5187-91. Epub 2005 Oct 3. PMID:16202589 Page seeded by OCA on Sat May 3 21:00:06 2008

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OCA

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