2bz8

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[[Image:2bz8.gif|left|200px]]
[[Image:2bz8.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2bz8 |SIZE=350|CAPTION= <scene name='initialview01'>2bz8</scene>, resolution 2.00&Aring;
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The line below this paragraph, containing "STRUCTURE_2bz8", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Na+Binding+Site+For+Chain+B'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE=
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|DOMAIN=
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{{STRUCTURE_2bz8| PDB=2bz8 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bz8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bz8 OCA], [http://www.ebi.ac.uk/pdbsum/2bz8 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2bz8 RCSB]</span>
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}}
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'''N-TERMINAL SH3 DOMAIN OF CIN85 BOUND TO CBL-B PEPTIDE'''
'''N-TERMINAL SH3 DOMAIN OF CIN85 BOUND TO CBL-B PEPTIDE'''
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[[Category: Cardenes, N.]]
[[Category: Cardenes, N.]]
[[Category: Moncalian, G.]]
[[Category: Moncalian, G.]]
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[[Category: cbl ubiquitin ligase]]
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[[Category: Cbl ubiquitin ligase]]
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[[Category: cin85 adaptor protein]]
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[[Category: Cin85 adaptor protein]]
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[[Category: endocytosis]]
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[[Category: Endocytosis]]
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[[Category: sh3 domain]]
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[[Category: Sh3 domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 21:00:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:14:01 2008''
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Revision as of 18:00, 3 May 2008

Image:2bz8.gif

Template:STRUCTURE 2bz8

N-TERMINAL SH3 DOMAIN OF CIN85 BOUND TO CBL-B PEPTIDE


Overview

The ubiquitin ligases c-Cbl and Cbl-b play a crucial role in receptor downregulation by mediating multiple monoubiquitination of receptors and promoting their sorting for lysosomal degradation. Their function is modulated through interactions with regulatory proteins including CIN85 and PIX, which recognize a proline-arginine motif in Cbl and thus promote or inhibit receptor endocytosis. We report the structures of SH3 domains of CIN85 and beta-PIX in complex with a proline-arginine peptide from Cbl-b. Both structures reveal a heterotrimeric complex containing two SH3 domains held together by a single peptide. Trimerization also occurs in solution and is facilitated by the pseudo-symmetrical peptide sequence. Moreover, ternary complexes of CIN85 and Cbl are formed in vivo and are important for the ability of Cbl to promote epidermal growth factor receptor (EGFR) downregulation. These results provide molecular explanations for a novel mechanism by which Cbl controls receptor downregulation.

About this Structure

2BZ8 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Cbl promotes clustering of endocytic adaptor proteins., Jozic D, Cardenes N, Deribe YL, Moncalian G, Hoeller D, Groemping Y, Dikic I, Rittinger K, Bravo J, Nat Struct Mol Biol. 2005 Nov;12(11):972-9. PMID:16228008 Page seeded by OCA on Sat May 3 21:00:18 2008

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