2c3b

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2c3b.gif|left|200px]]
[[Image:2c3b.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2c3b |SIZE=350|CAPTION= <scene name='initialview01'>2c3b</scene>, resolution 1.85&Aring;
+
The line below this paragraph, containing "STRUCTURE_2c3b", creates the "Structure Box" on the page.
-
|SITE= <scene name='pdbsite=AC1:So4+Binding+Site+For+Chain+B'>AC1</scene>
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2c3b| PDB=2c3b | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c3b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c3b OCA], [http://www.ebi.ac.uk/pdbsum/2c3b PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2c3b RCSB]</span>
+
-
}}
+
'''THE CRYSTAL STRUCTURE OF ASPERGILLUS FUMIGATUS CYCLOPHILIN REVEALS 3D DOMAIN SWAPPING OF A CENTRAL ELEMENT'''
'''THE CRYSTAL STRUCTURE OF ASPERGILLUS FUMIGATUS CYCLOPHILIN REVEALS 3D DOMAIN SWAPPING OF A CENTRAL ELEMENT'''
Line 32: Line 29:
[[Category: Scapozza, L.]]
[[Category: Scapozza, L.]]
[[Category: 3d domain swapping]]
[[Category: 3d domain swapping]]
-
[[Category: allergen]]
+
[[Category: Allergen]]
-
[[Category: asp f 11]]
+
[[Category: Asp f 11]]
-
[[Category: isomerase]]
+
[[Category: Isomerase]]
-
[[Category: misfolding]]
+
[[Category: Misfolding]]
-
[[Category: ppiase]]
+
[[Category: Ppiase]]
-
[[Category: rotamase]]
+
[[Category: Rotamase]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 21:11:08 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:15:46 2008''
+

Revision as of 18:11, 3 May 2008

Image:2c3b.gif

Template:STRUCTURE 2c3b

THE CRYSTAL STRUCTURE OF ASPERGILLUS FUMIGATUS CYCLOPHILIN REVEALS 3D DOMAIN SWAPPING OF A CENTRAL ELEMENT


Overview

The crystal structure of Aspergillus fumigatus cyclophilin (Asp f 11) was solved by the multiwavelength anomalous dispersion method and was refined to a resolution of 1.85 A with R and R(free) values of 18.9% and 21.4%, respectively. Many cyclophilin structures have been solved to date, all showing the same monomeric conformation. In contrast, the structure of A. fumigatus cyclophilin reveals dimerization by 3D domain swapping and represents one of the first proteins with a swapped central domain. The domain-swapped element consists of two beta strands and a subsequent loop carrying a conserved tryptophan. The tryptophan binds into the active site, inactivating cis-trans isomerization. This might be a means of biological regulation. The two hinge loops leave the protein prone to misfolding. In this context, alternative forms of 3D domain swapping that can lead to N- or C-terminally swapped dimers, oligomers, and aggregates are discussed.

About this Structure

2C3B is a Single protein structure of sequence from Aspergillus fumigatus. Full crystallographic information is available from OCA.

Reference

The crystal structure of Aspergillus fumigatus cyclophilin reveals 3D domain swapping of a central element., Limacher A, Kloer DP, Fluckiger S, Folkers G, Crameri R, Scapozza L, Structure. 2006 Feb;14(2):185-95. PMID:16472738 Page seeded by OCA on Sat May 3 21:11:08 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2c3b"
Personal tools