2c3s
From Proteopedia
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| - | + | {{STRUCTURE_2c3s| PDB=2c3s | SCENE= }} | |
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'''STRUCTURE OF SARS COV MAIN PROTEINASE AT 1.9 A (PH6.5)''' | '''STRUCTURE OF SARS COV MAIN PROTEINASE AT 1.9 A (PH6.5)''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2C3S is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_sars_coronavirus Human sars coronavirus]. This structure supersedes the now removed PDB entry | + | 2C3S is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_sars_coronavirus Human sars coronavirus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2bw6 2bw6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C3S OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Ooi, A.]] | [[Category: Ooi, A.]] | ||
[[Category: Xu, T.]] | [[Category: Xu, T.]] | ||
| - | [[Category: | + | [[Category: Sars cov,3c-like protease,main protease,hydrolase]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 21:12:24 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 18:12, 3 May 2008
STRUCTURE OF SARS COV MAIN PROTEINASE AT 1.9 A (PH6.5)
Overview
The 34 kDa main proteinase (Mpro) from the severe acute respiratory syndrome coronavirus (SARS-CoV) plays an important role in the virus life cycle through the specific processing of viral polyproteins. As such, SARS-CoV Mpro is a key target for the identification of specific inhibitors directed against the SARS virus. With a view to facilitating the development of such compounds, crystals were obtained of the enzyme at pH 6.5 in the orthorhombic space group P2(1)2(1)2 that diffract to a resolution of 1.9 A. These crystals contain one monomer per asymmetric unit and the biologically active dimer is generated via the crystallographic twofold axis. The conformation of the catalytic site indicates that the enzyme is active in the crystalline form and thus suitable for structure-based inhibition studies.
About this Structure
2C3S is a Single protein structure of sequence from Human sars coronavirus. This structure supersedes the now removed PDB entry 2bw6. Full crystallographic information is available from OCA.
Reference
Structure of the SARS coronavirus main proteinase as an active C2 crystallographic dimer., Xu T, Ooi A, Lee HC, Wilmouth R, Liu DX, Lescar J, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Nov 1;61(Pt, 11):964-6. Epub 2005 Oct 20. PMID:16511208 Page seeded by OCA on Sat May 3 21:12:24 2008
