2c4u

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[[Image:2c4u.gif|left|200px]]
[[Image:2c4u.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2c4u |SIZE=350|CAPTION= <scene name='initialview01'>2c4u</scene>, resolution 2.50&Aring;
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The line below this paragraph, containing "STRUCTURE_2c4u", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Gol+Binding+Site+For+Chain+C'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosyl-fluoride_synthase Adenosyl-fluoride synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.63 2.5.1.63] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2c4u| PDB=2c4u | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c4u OCA], [http://www.ebi.ac.uk/pdbsum/2c4u PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2c4u RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF THE APO FORM OF THE 5'-FLUORO-5'-DEOXYADENOSINE SYNTHASE ENZYME FROM STREPTOMYCES CATTLEYA'''
'''CRYSTAL STRUCTURE OF THE APO FORM OF THE 5'-FLUORO-5'-DEOXYADENOSINE SYNTHASE ENZYME FROM STREPTOMYCES CATTLEYA'''
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[[Category: Robinson, D A.]]
[[Category: Robinson, D A.]]
[[Category: 5'-fluorodeoxyadanosine synthase]]
[[Category: 5'-fluorodeoxyadanosine synthase]]
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[[Category: apo]]
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[[Category: Apo]]
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[[Category: fda]]
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[[Category: Fda]]
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[[Category: fluorinase]]
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[[Category: Fluorinase]]
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[[Category: sam]]
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[[Category: Sam]]
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[[Category: transferase]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 21:15:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:16:19 2008''
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Revision as of 18:15, 3 May 2008

Image:2c4u.gif

Template:STRUCTURE 2c4u

CRYSTAL STRUCTURE OF THE APO FORM OF THE 5'-FLUORO-5'-DEOXYADENOSINE SYNTHASE ENZYME FROM STREPTOMYCES CATTLEYA


Overview

The fluorinase enzyme from Streptomyces cattleya displays an unusual ability in biocatalysis in that it forms a C-F bond. We now report that the enzyme will accept 2'-deoxyadenosine in place of adenosine substrates, and structural evidence reveals a reorganisation in hydrogen bonding to accommodate this substrate series. It emerges from this study that the enzyme does not require a planar ribose conformation of the substrate to catalyse C-F bond formation.

About this Structure

2C4U is a Single protein structure of sequence from Streptomyces cattleya. Full crystallographic information is available from OCA.

Reference

Substrate specificity in enzymatic fluorination. The fluorinase from Streptomyces cattleya accepts 2'-deoxyadenosine substrates., Cobb SL, Deng H, McEwan AR, Naismith JH, O'Hagan D, Robinson DA, Org Biomol Chem. 2006 Apr 21;4(8):1458-60. Epub 2006 Mar 8. PMID:16604208 Page seeded by OCA on Sat May 3 21:15:13 2008

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