2c5d

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[[Image:2c5d.gif|left|200px]]
[[Image:2c5d.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2c5d |SIZE=350|CAPTION= <scene name='initialview01'>2c5d</scene>, resolution 3.3&Aring;
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The line below this paragraph, containing "STRUCTURE_2c5d", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Nag+Binding+Site+For+Chain+B'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_2c5d| PDB=2c5d | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c5d OCA], [http://www.ebi.ac.uk/pdbsum/2c5d PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2c5d RCSB]</span>
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}}
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'''STRUCTURE OF A MINIMAL GAS6-AXL COMPLEX'''
'''STRUCTURE OF A MINIMAL GAS6-AXL COMPLEX'''
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[[Category: Timpl, R.]]
[[Category: Timpl, R.]]
[[Category: Ullrich, A.]]
[[Category: Ullrich, A.]]
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[[Category: egf-like domain]]
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[[Category: Egf-like domain]]
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[[Category: growth regulation]]
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[[Category: Growth regulation]]
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[[Category: immunoglobulin-like domain]]
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[[Category: Immunoglobulin-like domain]]
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[[Category: laminin g-like domain]]
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[[Category: Laminin g-like domain]]
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[[Category: receptor]]
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[[Category: Receptor]]
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[[Category: receptor tyrosine kinase]]
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[[Category: Receptor tyrosine kinase]]
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[[Category: vitamin k-dependent protein]]
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[[Category: Vitamin k-dependent protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 21:16:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:16:35 2008''
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Revision as of 18:16, 3 May 2008

Image:2c5d.gif

Template:STRUCTURE 2c5d

STRUCTURE OF A MINIMAL GAS6-AXL COMPLEX


Overview

Receptor tyrosine kinases of the Axl family are activated by the vitamin K-dependent protein Gas6. Axl signalling plays important roles in cancer, spermatogenesis, immunity, and platelet function. The crystal structure at 3.3 A resolution of a minimal human Gas6/Axl complex reveals an assembly of 2:2 stoichiometry, in which the two immunoglobulin-like domains of the Axl ectodomain are crosslinked by the first laminin G-like domain of Gas6, with no direct Axl/Axl or Gas6/Gas6 contacts. There are two distinct Gas6/Axl contacts of very different size, both featuring interactions between edge beta-strands. Structure-based mutagenesis, protein binding assays and receptor activation experiments demonstrate that both the major and minor Gas6 binding sites are required for productive transmembrane signalling. Gas6-mediated Axl dimerisation is likely to occur in two steps, with a high-affinity 1:1 Gas6/Axl complex forming first. Only the minor Gas6 binding site is highly conserved in the other Axl family receptors, Sky/Tyro3 and Mer. Specificity at the major contact is suggested to result from the segregation of charged and apolar residues to opposite faces of the newly formed beta-sheet.

About this Structure

2C5D is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for Gas6-Axl signalling., Sasaki T, Knyazev PG, Clout NJ, Cheburkin Y, Gohring W, Ullrich A, Timpl R, Hohenester E, EMBO J. 2006 Jan 11;25(1):80-7. Epub 2005 Dec 15. PMID:16362042 Page seeded by OCA on Sat May 3 21:16:38 2008

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