2c6a
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:2c6a.gif|left|200px]] | [[Image:2c6a.gif|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_2c6a", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
| - | | | + | or leave the SCENE parameter empty for the default display. |
| - | | | + | --> |
| - | + | {{STRUCTURE_2c6a| PDB=2c6a | SCENE= }} | |
| - | + | ||
| - | + | ||
| - | }} | + | |
'''SOLUTION STRUCTURE OF THE C4 ZINC-FINGER DOMAIN OF HDM2''' | '''SOLUTION STRUCTURE OF THE C4 ZINC-FINGER DOMAIN OF HDM2''' | ||
| Line 30: | Line 27: | ||
[[Category: Fersht, A R.]] | [[Category: Fersht, A R.]] | ||
[[Category: Yu, G W.]] | [[Category: Yu, G W.]] | ||
| - | [[Category: | + | [[Category: Alternative splicing]] |
| - | [[Category: | + | [[Category: Human mdm2]] |
| - | [[Category: | + | [[Category: Ligase]] |
| - | [[Category: | + | [[Category: Metal-binding]] |
| - | [[Category: | + | [[Category: Nuclear protein]] |
| - | [[Category: | + | [[Category: Phosphorylation]] |
| - | [[Category: | + | [[Category: Proto-oncogene]] |
| - | [[Category: | + | [[Category: Ubl conjugation pathway]] |
| - | [[Category: | + | [[Category: Zinc]] |
| - | [[Category: | + | [[Category: Zinc finger]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 21:19:19 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 18:19, 3 May 2008
SOLUTION STRUCTURE OF THE C4 ZINC-FINGER DOMAIN OF HDM2
Overview
HDM2 is a ubiquitin E3 ligase that is a key negative regulator of the tumor suppressor p53. Here, we report the determination of the solution structure of the C4 zinc finger domain of HDM2 using multidimensional NMR. The HDM2 C4 zinc finger domain has a fold consisting of a 3(10) helix followed by four beta-strands, which shares significant structural similarity to the zinc ribbon protein family. Family based sequence analysis identified two putative binding sites, one of which resembles an RNA binding motif.
About this Structure
2C6A is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Solution structure of the C4 zinc finger domain of HDM2., Yu GW, Allen MD, Andreeva A, Fersht AR, Bycroft M, Protein Sci. 2006 Feb;15(2):384-9. Epub 2005 Dec 29. PMID:16385008 Page seeded by OCA on Sat May 3 21:19:19 2008
