2c9v

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2c9v.gif|left|200px]]
[[Image:2c9v.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2c9v |SIZE=350|CAPTION= <scene name='initialview01'>2c9v</scene>, resolution 1.07&Aring;
+
The line below this paragraph, containing "STRUCTURE_2c9v", creates the "Structure Box" on the page.
-
|SITE= <scene name='pdbsite=AC1:So4+Binding+Site+For+Chain+F'>AC1</scene>
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2c9v| PDB=2c9v | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c9v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c9v OCA], [http://www.ebi.ac.uk/pdbsum/2c9v PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2c9v RCSB]</span>
+
-
}}
+
'''ATOMIC RESOLUTION STRUCTURE OF CU-ZN HUMAN SUPEROXIDE DISMUTASE'''
'''ATOMIC RESOLUTION STRUCTURE OF CU-ZN HUMAN SUPEROXIDE DISMUTASE'''
Line 32: Line 29:
[[Category: Strange, R W.]]
[[Category: Strange, R W.]]
[[Category: Valentine, J S.]]
[[Category: Valentine, J S.]]
-
[[Category: acetylation]]
+
[[Category: Acetylation]]
-
[[Category: amyotrophic lateral sclerosis]]
+
[[Category: Amyotrophic lateral sclerosis]]
-
[[Category: antioxidant]]
+
[[Category: Antioxidant]]
-
[[Category: copper]]
+
[[Category: Copper]]
-
[[Category: disease mutation]]
+
[[Category: Disease mutation]]
-
[[Category: human cu]]
+
[[Category: Human cu]]
-
[[Category: metal-binding]]
+
[[Category: Metal-binding]]
-
[[Category: oxidoreductase]]
+
[[Category: Oxidoreductase]]
-
[[Category: oxioreductase]]
+
[[Category: Oxioreductase]]
-
[[Category: zinc]]
+
[[Category: Zinc]]
-
[[Category: zn superoxide dismutase]]
+
[[Category: Zn superoxide dismutase]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 21:31:51 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:18:29 2008''
+

Revision as of 18:31, 3 May 2008

Image:2c9v.gif

Template:STRUCTURE 2c9v

ATOMIC RESOLUTION STRUCTURE OF CU-ZN HUMAN SUPEROXIDE DISMUTASE


Overview

Human Cu-Zn superoxide dismutase (SOD1) protects cells from the effects of oxidative stress. Mutations in SOD1 are linked to the familial form of amyotrophic lateral sclerosis. Several hypotheses for their toxicity involve the mis-metallation of the enzyme. We present atomic-resolution crystal structures and biophysical data for human SOD1 in three metallation states: Zn-Zn, Cu-Zn and as-isolated. These data represent the first atomic-resolution structures for human SOD1, the first structure of a reduced SOD1, and the first structure of a fully Zn-substituted SOD1 enzyme. Recombinantly expressed as-isolated SOD1 contains a mixture of Zn and Cu at the Cu-binding site. The Zn-Zn structure appears to be at least as stable as the correctly (Cu-Zn) metallated enzyme. These data raise the possibility that in a cellular environment with low availability of free copper, Zn-Zn may be the preferred metallation state of SOD1 prior to its interaction with the copper chaperone.

About this Structure

2C9V is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Variable metallation of human superoxide dismutase: atomic resolution crystal structures of Cu-Zn, Zn-Zn and as-isolated wild-type enzymes., Strange RW, Antonyuk SV, Hough MA, Doucette PA, Valentine JS, Hasnain SS, J Mol Biol. 2006 Mar 10;356(5):1152-62. Epub 2005 Dec 12. PMID:16406071 Page seeded by OCA on Sat May 3 21:31:51 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2c9v"
Personal tools