2ca7

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2ca7.gif|left|200px]]
[[Image:2ca7.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2ca7 |SIZE=350|CAPTION= <scene name='initialview01'>2ca7</scene>
+
The line below this paragraph, containing "STRUCTURE_2ca7", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND=
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2ca7| PDB=2ca7 | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ca7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ca7 OCA], [http://www.ebi.ac.uk/pdbsum/2ca7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ca7 RCSB]</span>
+
-
}}
+
'''CONKUNITZIN-S1 IS THE FIRST MEMBER OF A NEW KUNITZ-TYPE NEUROTOXIN FAMILY- STRUCTURAL AND FUNCTIONAL CHARACTERIZATION'''
'''CONKUNITZIN-S1 IS THE FIRST MEMBER OF A NEW KUNITZ-TYPE NEUROTOXIN FAMILY- STRUCTURAL AND FUNCTIONAL CHARACTERIZATION'''
Line 36: Line 33:
[[Category: Vijayan, V.]]
[[Category: Vijayan, V.]]
[[Category: Zweckstetter, M.]]
[[Category: Zweckstetter, M.]]
-
[[Category: conkunitzin]]
+
[[Category: Conkunitzin]]
-
[[Category: kunitz-domain]]
+
[[Category: Kunitz-domain]]
-
[[Category: kunitz-type fold]]
+
[[Category: Kunitz-type fold]]
-
[[Category: neurotoxin]]
+
[[Category: Neurotoxin]]
-
[[Category: potassium channel inhibitor]]
+
[[Category: Potassium channel inhibitor]]
-
[[Category: toxin]]
+
[[Category: Toxin]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 21:33:41 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:18:43 2008''
+

Revision as of 18:33, 3 May 2008

Image:2ca7.gif

Template:STRUCTURE 2ca7

CONKUNITZIN-S1 IS THE FIRST MEMBER OF A NEW KUNITZ-TYPE NEUROTOXIN FAMILY- STRUCTURAL AND FUNCTIONAL CHARACTERIZATION


Overview

Conkunitzin-S1 (Conk-S1) is a 60-residue neurotoxin from the venom of the cone snail Conus striatus that interacts with voltage-gated potassium channels. Conk-S1 shares sequence homology with Kunitz-type proteins but contains only two out of the three highly conserved cysteine bridges, which are typically found in these small, basic protein modules. In this study the three-dimensional structure of Conk-S1 has been solved by multidimensional NMR spectroscopy. The solution structure of recombinant Conk-S1 shows that a Kunitz fold is present, even though one of the highly conserved disulfide cross-links is missing. Introduction of a third, homologous disulfide bond into Conk-S1 results in a functional toxin with similar affinity for Shaker potassium channels. The affinity of Conk-S1 can be enhanced by a pore mutation within the Shaker channel pore indicating an interaction of Conk-S1 with the vestibule of potassium channels.

About this Structure

2CA7 is a Single protein structure of sequence from Conus striatus. Full crystallographic information is available from OCA.

Reference

Conkunitzin-S1 is the first member of a new Kunitz-type neurotoxin family. Structural and functional characterization., Bayrhuber M, Vijayan V, Ferber M, Graf R, Korukottu J, Imperial J, Garrett JE, Olivera BM, Terlau H, Zweckstetter M, Becker S, J Biol Chem. 2005 Jun 24;280(25):23766-70. Epub 2005 Apr 15. PMID:15833744 Page seeded by OCA on Sat May 3 21:33:41 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2ca7"
Personal tools