2cas
From Proteopedia
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[[Image:2cas.gif|left|200px]] | [[Image:2cas.gif|left|200px]] | ||
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'''THE CANINE PARVOVIRUS EMPTY CAPSID STRUCTURE''' | '''THE CANINE PARVOVIRUS EMPTY CAPSID STRUCTURE''' | ||
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[[Category: Rossmann, M.]] | [[Category: Rossmann, M.]] | ||
[[Category: Wu, H.]] | [[Category: Wu, H.]] | ||
| - | [[Category: | + | [[Category: Icosahedral virus]] |
| - | [[Category: | + | [[Category: Parvovirus coat protein]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 21:36:04 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 18:36, 3 May 2008
THE CANINE PARVOVIRUS EMPTY CAPSID STRUCTURE
Overview
The structure of empty canine parvovirus capsids shows that residues 37 to the carboxy-terminal residue 584 (VP2 numbering) are ordered in each of the 60 subunits. The central structural motif of each subunit is the eight-stranded antiparallel beta-barrel that has been found in many other virus structures. Five beta-hairpin turns form a beta-cylindrical structure at each icosahedral 5-fold axis. The N-terminal glycine-rich sequence can be accommodated within this cylinder without excessive steric hindrance, consistent with the electron density distribution. By far the largest conformational differences between the full and empty virus were found in the region where some ordered DNA has been observed to bind in canine parvovirus full particles. Extensive interactions among 3-fold related subunits indicate that a trimeric subunit might be a viral assembly intermediate.
About this Structure
2CAS is a Single protein structure of sequence from Canine parvovirus. Full crystallographic information is available from OCA.
Reference
The canine parvovirus empty capsid structure., Wu H, Rossmann MG, J Mol Biol. 1993 Sep 20;233(2):231-44. PMID:8377200 Page seeded by OCA on Sat May 3 21:36:04 2008
