2cbf

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[[Image:2cbf.gif|left|200px]]
[[Image:2cbf.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2cbf |SIZE=350|CAPTION= <scene name='initialview01'>2cbf</scene>, resolution 3.1&Aring;
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The line below this paragraph, containing "STRUCTURE_2cbf", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=FLP:Two+Regions+Contain+Significantly+Altered+Locations+Rela+...'>FLP</scene> and <scene name='pdbsite=SAH:S-Adenosyl-Homocysteine+Binding+Site.+Crystals+Formed+In+...'>SAH</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Precorrin-4_C(11)-methyltransferase Precorrin-4 C(11)-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.133 2.1.1.133] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= CBIF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1404 Bacillus megaterium])
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-->
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|DOMAIN=
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{{STRUCTURE_2cbf| PDB=2cbf | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cbf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cbf OCA], [http://www.ebi.ac.uk/pdbsum/2cbf PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2cbf RCSB]</span>
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}}
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'''THE X-RAY STRUCTURE OF A COBALAMIN BIOSYNTHETIC ENZYME, COBALT PRECORRIN-4 METHYLTRANSFERASE, CBIF, FROM BACILLUS MEGATERIUM, WITH THE HIS-TAG CLEAVED OFF'''
'''THE X-RAY STRUCTURE OF A COBALAMIN BIOSYNTHETIC ENZYME, COBALT PRECORRIN-4 METHYLTRANSFERASE, CBIF, FROM BACILLUS MEGATERIUM, WITH THE HIS-TAG CLEAVED OFF'''
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The X-ray structure of a cobalamin biosynthetic enzyme, cobalt-precorrin-4 methyltransferase., Schubert HL, Wilson KS, Raux E, Woodcock SC, Warren MJ, Nat Struct Biol. 1998 Jul;5(7):585-92. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9665173 9665173]
The X-ray structure of a cobalamin biosynthetic enzyme, cobalt-precorrin-4 methyltransferase., Schubert HL, Wilson KS, Raux E, Woodcock SC, Warren MJ, Nat Struct Biol. 1998 Jul;5(7):585-92. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9665173 9665173]
[[Category: Bacillus megaterium]]
[[Category: Bacillus megaterium]]
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[[Category: Precorrin-4 C(11)-methyltransferase]]
 
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Raux, E.]]
[[Category: Raux, E.]]
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[[Category: Wilson, K S.]]
[[Category: Wilson, K S.]]
[[Category: Woodcock, S C.]]
[[Category: Woodcock, S C.]]
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[[Category: cobalamin biosynthesis]]
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[[Category: Cobalamin biosynthesis]]
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[[Category: methylase]]
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[[Category: Methylase]]
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[[Category: precorrin-4 methyltransferase]]
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[[Category: Precorrin-4 methyltransferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 21:39:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:19:05 2008''
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Revision as of 18:39, 3 May 2008

Image:2cbf.gif

Template:STRUCTURE 2cbf

THE X-RAY STRUCTURE OF A COBALAMIN BIOSYNTHETIC ENZYME, COBALT PRECORRIN-4 METHYLTRANSFERASE, CBIF, FROM BACILLUS MEGATERIUM, WITH THE HIS-TAG CLEAVED OFF


Overview

Biosynthesis of the corrin ring of vitamin B12 requires the action of six S-adenosyl-L-methionine (AdoMet) dependent transmethylases, closely related in sequence. The first X-ray structure of one of these, cobalt-precorrin-4 transmethylase, CbiF, from Bacillus megaterium has been determined to a resolution of 2.4 A. CbiF contains two alphabeta domains forming a trough in which S-adenosyl-L-homocysteine (AdoHcy) binds. The location of AdoHcy and a number of conserved residues, helps define the precorrin binding site. A second crystal form determined at 3.1 A resolution highlights the flexibility of two loops around this site. CbiF employs a unique mode of AdoHcy binding and represents a new class of transmethylase.

About this Structure

2CBF is a Single protein structure of sequence from Bacillus megaterium. Full crystallographic information is available from OCA.

Reference

The X-ray structure of a cobalamin biosynthetic enzyme, cobalt-precorrin-4 methyltransferase., Schubert HL, Wilson KS, Raux E, Woodcock SC, Warren MJ, Nat Struct Biol. 1998 Jul;5(7):585-92. PMID:9665173 Page seeded by OCA on Sat May 3 21:39:05 2008

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