2cc3

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[[Image:2cc3.gif|left|200px]]
[[Image:2cc3.gif|left|200px]]
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{{Structure
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|PDB= 2cc3 |SIZE=350|CAPTION= <scene name='initialview01'>2cc3</scene>, resolution 2.20&Aring;
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The line below this paragraph, containing "STRUCTURE_2cc3", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Mpd+Binding+Site+For+Chain+B'>AC1</scene>
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|LIGAND= <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>
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{{STRUCTURE_2cc3| PDB=2cc3 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cc3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cc3 OCA], [http://www.ebi.ac.uk/pdbsum/2cc3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2cc3 RCSB]</span>
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}}
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'''STRUCTURE OF AGROBACTERIUM TUMEFACIENS VIRB8 PROTEIN'''
'''STRUCTURE OF AGROBACTERIUM TUMEFACIENS VIRB8 PROTEIN'''
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[[Category: Ward, D.]]
[[Category: Ward, D.]]
[[Category: Zambryski, P C.]]
[[Category: Zambryski, P C.]]
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[[Category: agrobacterium]]
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[[Category: Agrobacterium]]
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[[Category: consurf]]
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[[Category: Consurf]]
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[[Category: type iv secretion system]]
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[[Category: Type iv secretion system]]
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[[Category: virb8]]
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[[Category: Virb8]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 21:44:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:19:24 2008''
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Revision as of 18:44, 3 May 2008

Image:2cc3.gif

Template:STRUCTURE 2cc3

STRUCTURE OF AGROBACTERIUM TUMEFACIENS VIRB8 PROTEIN


Overview

Bacterial type IV secretion systems (T4SS) translocate DNA and/or proteins to recipient cells, thus providing a mechanism for conjugative transfer of genetic material and bacterial pathogenesis. Here we describe the first structure of a core component from the archetypal Agrobacterium tumefaciens T4SS: the 2.2-A resolution crystal structure of the VirB8 periplasmic domain (pVirB8(AT)). VirB8 forms a dimer in the crystal, and we identify residues likely important for stabilization of the dimer interface. Structural comparison of pVirB8(AT) with Brucella suis VirB8 confirms that the monomers have a similar fold. In addition, the pVirB8(AT) dimer superimposes very closely on the B. suis VirB8 dimer, supporting the proposal that dimer formation in the crystal reflects self-interactions that are biologically significant. The evolutionary conservation level for each residue was obtained from a data set of 84 VirB8 homologs and projected onto the protein structure to indicate conserved surface patches that likely contact other T4SS proteins.

About this Structure

2CC3 is a Single protein structure of sequence from Agrobacterium tumefaciens. Full crystallographic information is available from OCA.

Reference

Agrobacterium tumefaciens VirB8 structure reveals potential protein-protein interaction sites., Bailey S, Ward D, Middleton R, Grossmann JG, Zambryski PC, Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2582-7. Epub 2006 Feb 15. PMID:16481621 Page seeded by OCA on Sat May 3 21:44:52 2008

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