2cdq

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[[Image:2cdq.gif|left|200px]]
[[Image:2cdq.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2cdq |SIZE=350|CAPTION= <scene name='initialview01'>2cdq</scene>, resolution 2.85&Aring;
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The line below this paragraph, containing "STRUCTURE_2cdq", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Tar+Binding+Site+For+Chain+B'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=LYS:LYSINE'>LYS</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=TAR:D(-)-TARTARIC+ACID'>TAR</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Aspartate_kinase Aspartate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.2.4 2.7.2.4] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2cdq| PDB=2cdq | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cdq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdq OCA], [http://www.ebi.ac.uk/pdbsum/2cdq PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2cdq RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA ASPARTATE KINASE COMPLEXED WITH LYSINE AND S-ADENOSYLMETHIONINE'''
'''CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA ASPARTATE KINASE COMPLEXED WITH LYSINE AND S-ADENOSYLMETHIONINE'''
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[[Category: Mas-Droux, C.]]
[[Category: Mas-Droux, C.]]
[[Category: Robert-Genthon, M.]]
[[Category: Robert-Genthon, M.]]
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[[Category: act domain]]
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[[Category: Act domain]]
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[[Category: allosteric effector]]
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[[Category: Allosteric effector]]
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[[Category: allostery]]
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[[Category: Allostery]]
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[[Category: amino acid biosynthesis]]
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[[Category: Amino acid biosynthesis]]
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[[Category: amino acid metabolism]]
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[[Category: Amino acid metabolism]]
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[[Category: aspartate kinase]]
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[[Category: Aspartate kinase]]
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[[Category: lysine]]
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[[Category: Lysine]]
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[[Category: plant]]
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[[Category: Plant]]
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[[Category: s-adenosylmethionine]]
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[[Category: S-adenosylmethionine]]
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[[Category: transferase]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 21:53:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:20:02 2008''
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Revision as of 18:53, 3 May 2008

Image:2cdq.gif

Template:STRUCTURE 2cdq

CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA ASPARTATE KINASE COMPLEXED WITH LYSINE AND S-ADENOSYLMETHIONINE


Overview

Asp kinase catalyzes the first step of the Asp-derived essential amino acid pathway in plants and microorganisms. Depending on the source organism, this enzyme contains up to four regulatory ACT domains and exhibits several isoforms under the control of a great variety of allosteric effectors. We report here the dimeric structure of a Lys and S-adenosylmethionine-sensitive Asp kinase isoform from Arabidopsis thaliana in complex with its two inhibitors. This work reveals the structure of an Asp kinase and an enzyme containing two ACT domains cocrystallized with its effectors. Only one ACT domain (ACT1) is implicated in effector binding. A loop involved in the binding of Lys and S-adenosylmethionine provides an explanation for the synergistic inhibition by these effectors. The presence of S-adenosylmethionine in the regulatory domain indicates that ACT domains are also able to bind nucleotides. The organization of ACT domains in the present structure is different from that observed in Thr deaminase and in the regulatory subunit of acetohydroxyacid synthase III.

About this Structure

2CDQ is a Single protein structure of sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA.

Reference

A novel organization of ACT domains in allosteric enzymes revealed by the crystal structure of Arabidopsis aspartate kinase., Mas-Droux C, Curien G, Robert-Genthon M, Laurencin M, Ferrer JL, Dumas R, Plant Cell. 2006 Jul;18(7):1681-92. Epub 2006 May 26. PMID:16731588 Page seeded by OCA on Sat May 3 21:53:50 2008

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