2cfp

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[[Image:2cfp.gif|left|200px]]
[[Image:2cfp.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2cfp |SIZE=350|CAPTION= <scene name='initialview01'>2cfp</scene>, resolution 3.30&Aring;
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The line below this paragraph, containing "STRUCTURE_2cfp", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC2:Hg+Binding+Site+For+Chain+A'>AC2</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_2cfp| PDB=2cfp | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cfp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cfp OCA], [http://www.ebi.ac.uk/pdbsum/2cfp PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2cfp RCSB]</span>
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}}
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'''SUGAR FREE LACTOSE PERMEASE AT ACIDIC PH'''
'''SUGAR FREE LACTOSE PERMEASE AT ACIDIC PH'''
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[[Category: Mirza, O.]]
[[Category: Mirza, O.]]
[[Category: Verner, G.]]
[[Category: Verner, G.]]
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[[Category: formylation]]
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[[Category: Formylation]]
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[[Category: lactose permease]]
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[[Category: Lactose permease]]
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[[Category: lactose/h+ symport]]
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[[Category: Lactose/h+ symport]]
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[[Category: sugar transport]]
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[[Category: Sugar transport]]
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[[Category: transmembrane]]
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[[Category: Transmembrane]]
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[[Category: transport mechanism]]
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[[Category: Transport mechanism]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 22:01:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:20:48 2008''
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Revision as of 19:01, 3 May 2008

Image:2cfp.gif

Template:STRUCTURE 2cfp

SUGAR FREE LACTOSE PERMEASE AT ACIDIC PH


Overview

Cation-coupled active transport is an essential cellular process found ubiquitously in all living organisms. Here, we present two novel ligand-free X-ray structures of the lactose permease (LacY) of Escherichia coli determined at acidic and neutral pH, and propose a model for the mechanism of coupling between lactose and H+ translocation. No sugar-binding site is observed in the absence of ligand, and deprotonation of the key residue Glu269 is associated with ligand binding. Thus, substrate induces formation of the sugar-binding site, as well as the initial step in H+ transduction.

About this Structure

2CFP is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structural evidence for induced fit and a mechanism for sugar/H+ symport in LacY., Mirza O, Guan L, Verner G, Iwata S, Kaback HR, EMBO J. 2006 Mar 22;25(6):1177-83. Epub 2006 Mar 9. PMID:16525509 Page seeded by OCA on Sat May 3 22:01:44 2008

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