2chk

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2chk.gif|left|200px]]
[[Image:2chk.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2chk |SIZE=350|CAPTION= <scene name='initialview01'>2chk</scene>
+
The line below this paragraph, containing "STRUCTURE_2chk", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=LCG:[(1R,3R,4R,7S)-7-HYDROXY-3-(GUANIN-9-YL)-2,5-DIOXABICYCLO[2.2.1]HEPT-1-YL]METHYL+DIHYDROGEN+PHOSPHATE'>LCG</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2chk| PDB=2chk | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2chk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2chk OCA], [http://www.ebi.ac.uk/pdbsum/2chk PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2chk RCSB]</span>
+
-
}}
+
'''NMR STRUCTURE OF TLLLLT QUADRUPLEX'''
'''NMR STRUCTURE OF TLLLLT QUADRUPLEX'''
Line 19: Line 16:
==About this Structure==
==About this Structure==
-
2CHK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CHK OCA].
+
2CHK is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CHK OCA].
==Reference==
==Reference==
Line 26: Line 23:
[[Category: Nielsen, J T.]]
[[Category: Nielsen, J T.]]
[[Category: Petersen, M.]]
[[Category: Petersen, M.]]
-
[[Category: lna]]
+
[[Category: Lna]]
-
[[Category: locked nucleic acid]]
+
[[Category: Locked nucleic acid]]
-
[[Category: nucleic acid]]
+
[[Category: Nucleic acid]]
-
[[Category: quadruplex]]
+
[[Category: Quadruplex]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 22:09:29 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:21:34 2008''
+

Revision as of 19:09, 3 May 2008

Image:2chk.gif

Template:STRUCTURE 2chk

NMR STRUCTURE OF TLLLLT QUADRUPLEX


Overview

We have determined the NMR solution structures of the quadruplexes formed by d(TGLGLT) and d(TL4T), where L denotes LNA (locked nucleic acid) modified G-residues. Both structures are tetrameric, parallel and right-handed and the native global fold of the corresponding DNA quadruplex is retained upon introduction of the LNA nucleotides. However, local structural alterations are observed owing to the locked LNA sugars. In particular, a distinct change in the sugar-phosphate backbone is observed at the G2pL3 and L2pL3 base steps and sequence dependent changes in the twist between tetrads are also seen. Both the LNA modified quadruplexes have raised thermostability as compared to the DNA quadruplex. The quadruplex-forming capability of d(TGLGLT) is of particular interest as it expands the design flexibility for stable parallel LNA quadruplexes and shows that LNA nucleotides can be mixed with DNA or other modified nucleic acids. As such, LNA-based quadruplexes can be decorated by a variety of chemical modifications. Such LNA quadruplex scaffolds might find applications in the developing field of nanobiotechnology.

About this Structure

2CHK is a Single protein structure. Full crystallographic information is available from OCA.

Reference

NMR solution structures of LNA (locked nucleic acid) modified quadruplexes., Nielsen JT, Arar K, Petersen M, Nucleic Acids Res. 2006 Apr 13;34(7):2006-14. Print 2006. PMID:16614450 Page seeded by OCA on Sat May 3 22:09:29 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2chk"
Personal tools