This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2cii

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2cii.gif|left|200px]]
[[Image:2cii.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2cii |SIZE=350|CAPTION= <scene name='initialview01'>2cii</scene>, resolution 2.55&Aring;
+
The line below this paragraph, containing "STRUCTURE_2cii", creates the "Structure Box" on the page.
-
|SITE= <scene name='pdbsite=AC1:Gol+Binding+Site+For+Chain+A'>AC1</scene>
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2cii| PDB=2cii | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cii FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cii OCA], [http://www.ebi.ac.uk/pdbsum/2cii PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2cii RCSB]</span>
+
-
}}
+
'''THE CRYSTAL STRUCTURE OF H-2DB COMPLEXED WITH A PARTIAL PEPTIDE EPITOPE SUGGESTS AN MHC CLASS I ASSEMBLY-INTERMEDIATE'''
'''THE CRYSTAL STRUCTURE OF H-2DB COMPLEXED WITH A PARTIAL PEPTIDE EPITOPE SUGGESTS AN MHC CLASS I ASSEMBLY-INTERMEDIATE'''
Line 32: Line 29:
[[Category: Kojima, M.]]
[[Category: Kojima, M.]]
[[Category: Tormo, J.]]
[[Category: Tormo, J.]]
-
[[Category: complex (antigen/peptide)]]
+
[[Category: Glycoprotein]]
-
[[Category: glycoprotein]]
+
[[Category: Immune response]]
-
[[Category: immune response]]
+
[[Category: Immunoglobulin domain]]
-
[[Category: immunoglobulin domain]]
+
[[Category: Membrane]]
-
[[Category: membrane]]
+
[[Category: Mhc class i]]
-
[[Category: mhc class i]]
+
[[Category: Mhc i]]
-
[[Category: mhc i]]
+
[[Category: Peptide binding]]
-
[[Category: peptide binding]]
+
[[Category: Pyrrolidone carboxylic acid]]
-
[[Category: pyrrolidone carboxylic acid]]
+
[[Category: Sendai virus]]
-
[[Category: sendai virus]]
+
[[Category: Transmembrane]]
-
[[Category: transmembrane]]
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 22:13:21 2008''
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:21:59 2008''
+

Revision as of 19:13, 3 May 2008

Image:2cii.gif

Template:STRUCTURE 2cii

THE CRYSTAL STRUCTURE OF H-2DB COMPLEXED WITH A PARTIAL PEPTIDE EPITOPE SUGGESTS AN MHC CLASS I ASSEMBLY-INTERMEDIATE


Overview

In the absence of bound peptide ligands, major histocompatibility complex (MHC) class I molecules are unstable. In an attempt to determine the minimum requirement for peptide-dependent MHC class I stabilization, we have used short synthetic peptides derived from the Sendai virus nucleoprotein epitope (residues 324-332, 1FAPGNYPAL9) to promote its folding in vitro of H-2D(b). We found that H-2D(b) can be stabilized by the pentapeptide 5NYPAL9, which is equivalent to the C-terminal portion of the optimal nonapeptide and includes both the P5 and P9 anchor residues. We have crystallized the complex of the H-2D(b) molecule with the pentamer and determined the structure to show how a quasi-stable MHC class I molecule can be formed by occupancy of a single binding pocket in the peptide-binding groove.

About this Structure

2CII is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

Reference

The crystal structure of H-2D(b) complexed with a partial peptide epitope suggests a major histocompatibility complex class I assembly intermediate., Glithero A, Tormo J, Doering K, Kojima M, Jones EY, Elliott T, J Biol Chem. 2006 May 5;281(18):12699-704. Epub 2006 Feb 14. PMID:16478731 Page seeded by OCA on Sat May 3 22:13:21 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2cii"
Personal tools