2ckz

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[[Image:2ckz.gif|left|200px]]
[[Image:2ckz.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2ckz |SIZE=350|CAPTION= <scene name='initialview01'>2ckz</scene>, resolution 3.2&Aring;
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The line below this paragraph, containing "STRUCTURE_2ckz", creates the "Structure Box" on the page.
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|SITE=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_RNA_polymerase DNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.6 2.7.7.6] </span>
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{{STRUCTURE_2ckz| PDB=2ckz | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ckz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ckz OCA], [http://www.ebi.ac.uk/pdbsum/2ckz PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ckz RCSB]</span>
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'''X-RAY STRUCTURE OF RNA POLYMERASE III SUBCOMPLEX C17-C25.'''
'''X-RAY STRUCTURE OF RNA POLYMERASE III SUBCOMPLEX C17-C25.'''
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[[Category: Jasiak, A J.]]
[[Category: Jasiak, A J.]]
[[Category: Martens, B.]]
[[Category: Martens, B.]]
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[[Category: class iii gene transcription]]
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[[Category: Class iii gene transcription]]
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[[Category: dna-directed rna polymerase]]
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[[Category: Dna-directed rna polymerase]]
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[[Category: eukaryotic nucleic acid polymerase]]
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[[Category: Eukaryotic nucleic acid polymerase]]
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[[Category: hypothetical protein]]
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[[Category: Hypothetical protein]]
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[[Category: multiprotein complex]]
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[[Category: Multiprotein complex]]
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[[Category: nuclear protein]]
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[[Category: Nuclear protein]]
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[[Category: nucleotidyltransferase]]
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[[Category: Nucleotidyltransferase]]
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[[Category: transcription]]
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[[Category: Transcription]]
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[[Category: transferase]]
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[[Category: Transferase]]
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[[Category: trna synthesis]]
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[[Category: Trna synthesis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 22:23:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:22:59 2008''
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Revision as of 19:23, 3 May 2008

Image:2ckz.gif

Template:STRUCTURE 2ckz

X-RAY STRUCTURE OF RNA POLYMERASE III SUBCOMPLEX C17-C25.


Overview

We obtained an 11 subunit model of RNA polymerase (Pol) III by combining a homology model of the nine subunit core enzyme with a new X-ray structure of the subcomplex C17/25. Compared to Pol II, Pol III shows a conserved active center for RNA synthesis but a structurally different upstream face for specific initiation complex assembly during promoter selection. The Pol III upstream face includes a HRDC domain in subunit C17 that is translated by 35 A and rotated by 150 degrees compared to its Pol II counterpart. The HRDC domain is essential in vivo, folds independently in vitro, and, unlike other HRDC domains, shows no indication of nucleic acid binding. Thus, the HRDC domain is a functional module that could account for the role of C17 in Pol III promoter-specific initiation. During elongation, C17/25 may bind Pol III transcripts emerging from the adjacent exit pore, because the subcomplex binds to tRNA in vitro.

About this Structure

2CKZ is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structural biology of RNA polymerase III: subcomplex C17/25 X-ray structure and 11 subunit enzyme model., Jasiak AJ, Armache KJ, Martens B, Jansen RP, Cramer P, Mol Cell. 2006 Jul 7;23(1):71-81. PMID:16818233 Page seeded by OCA on Sat May 3 22:23:30 2008

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