2clt

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[[Image:2clt.gif|left|200px]]
[[Image:2clt.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2clt |SIZE=350|CAPTION= <scene name='initialview01'>2clt</scene>, resolution 2.67&Aring;
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The line below this paragraph, containing "STRUCTURE_2clt", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Zn+Binding+Site+For+Chain+B'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Interstitial_collagenase Interstitial collagenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.7 3.4.24.7] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_2clt| PDB=2clt | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2clt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2clt OCA], [http://www.ebi.ac.uk/pdbsum/2clt PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2clt RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF THE ACTIVE FORM (FULL-LENGTH) OF HUMAN FIBROBLAST COLLAGENASE.'''
'''CRYSTAL STRUCTURE OF THE ACTIVE FORM (FULL-LENGTH) OF HUMAN FIBROBLAST COLLAGENASE.'''
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[[Category: Nagase, H.]]
[[Category: Nagase, H.]]
[[Category: Visse, R.]]
[[Category: Visse, R.]]
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[[Category: autocatalytic cleavage]]
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[[Category: Autocatalytic cleavage]]
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[[Category: calcium]]
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[[Category: Calcium]]
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[[Category: collagen]]
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[[Category: Collagen]]
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[[Category: collagen degradation]]
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[[Category: Collagen degradation]]
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[[Category: extracellular matrix]]
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[[Category: Extracellular matrix]]
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[[Category: fibroblast collagenase]]
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[[Category: Fibroblast collagenase]]
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[[Category: glycoprotein]]
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[[Category: Glycoprotein]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: inhibitor-free]]
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[[Category: Inhibitor-free]]
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[[Category: matrix metalloproteinase]]
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[[Category: Matrix metalloproteinase]]
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[[Category: metal-binding]]
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[[Category: Metal-binding]]
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[[Category: metalloprotease]]
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[[Category: Metalloprotease]]
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[[Category: polymorphism]]
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[[Category: Polymorphism]]
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[[Category: protease]]
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[[Category: Protease]]
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[[Category: zinc]]
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[[Category: Zinc]]
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[[Category: zymogen]]
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[[Category: Zymogen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 22:27:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:23:15 2008''
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Revision as of 19:27, 3 May 2008

Image:2clt.gif


PDB ID 2clt

Drag the structure with the mouse to rotate
2clt, resolution 2.67Å ()
Ligands: ,
Activity: Interstitial collagenase, with EC number 3.4.24.7
Related: 1ayk, 1cge, 1cgf, 1cgl, 1hfc, 1su3, 2ayk, 2tcl, 3ayk, 4ayk, 966c
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE OF THE ACTIVE FORM (FULL-LENGTH) OF HUMAN FIBROBLAST COLLAGENASE.


Overview

The extracellular matrix is a dynamic environment that constantly undergoes remodelling and degradation during vital physiological processes such as angiogenesis, wound healing, and development. Unbalanced extracellular matrix breakdown is associated with many diseases such as arthritis, cancer and fibrosis. Interstitial collagen is degraded by matrix metalloproteinases with collagenolytic activity by MMP-1, MMP-8 and MMP-13, collectively known as the collagenases. Matrix metalloproteinase 1 (MMP-1) plays a pivotal role in degradation of interstitial collagen types I, II, and III. Here, we report the crystal structure of the active form of human MMP-1 at 2.67 A resolution. This is the first MMP-1 structure that is free of inhibitor and a water molecule essential for peptide hydrolysis is observed coordinated with the active site zinc. Comparing this structure with the human proMMP-1 shows significant structural differences, mainly in the relative orientation of the hemopexin domain, between the pro form and active form of the human enzyme.

About this Structure

2CLT is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of an active form of human MMP-1., Iyer S, Visse R, Nagase H, Acharya KR, J Mol Biol. 2006 Sep 8;362(1):78-88. Epub 2006 Aug 4. PMID:16890240 Page seeded by OCA on Sat May 3 22:27:11 2008

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