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2cmr

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[[Image:2cmr.jpg|left|200px]]
[[Image:2cmr.jpg|left|200px]]
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{{Structure
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{{STRUCTURE_2cmr| PDB=2cmr | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cmr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cmr OCA], [http://www.ebi.ac.uk/pdbsum/2cmr PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2cmr RCSB]</span>
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'''CRYSTAL STRUCTURE OF THE HIV-1 NEUTRALIZING ANTIBODY D5 FAB BOUND TO THE GP41 INNER-CORE MIMETIC 5-HELIX'''
'''CRYSTAL STRUCTURE OF THE HIV-1 NEUTRALIZING ANTIBODY D5 FAB BOUND TO THE GP41 INNER-CORE MIMETIC 5-HELIX'''
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[[Category: Miller, M D.]]
[[Category: Miller, M D.]]
[[Category: Pessi, A.]]
[[Category: Pessi, A.]]
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[[Category: aid]]
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[[Category: Aid]]
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[[Category: envelope protein]]
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[[Category: Envelope protein]]
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[[Category: gp41]]
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[[Category: Gp41]]
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[[Category: hiv]]
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[[Category: Hiv]]
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[[Category: immunoglobulin]]
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[[Category: Immunoglobulin]]
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[[Category: immunoglobulin complex]]
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[[Category: Immunoglobulin complex]]
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[[Category: immunoglobulin domain]]
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[[Category: Immunoglobulin domain]]
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[[Category: membrane]]
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[[Category: Membrane]]
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[[Category: mhc i]]
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[[Category: Mhc i]]
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[[Category: neutralization]]
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[[Category: Neutralization]]
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[[Category: transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 22:31:41 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:23:43 2008''
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Revision as of 19:31, 3 May 2008

Image:2cmr.jpg

Template:STRUCTURE 2cmr

CRYSTAL STRUCTURE OF THE HIV-1 NEUTRALIZING ANTIBODY D5 FAB BOUND TO THE GP41 INNER-CORE MIMETIC 5-HELIX


Overview

Elicitation of potent and broadly neutralizing antibodies is an important goal in designing an effective human immunodeficiency virus-1 (HIV-1) vaccine. The HIV-1 gp41 inner-core trimer represents a functionally and structurally conserved target for therapeutics. Here we report the 2.0-A-resolution crystal structure of the complex between the antigen-binding fragment of D5, an HIV-1 cross-neutralizing antibody, and 5-helix, a gp41 inner-core mimetic. Both binding and neutralization depend on residues in the D5 CDR H2 loop protruding into the conserved gp41 hydrophobic pocket, as well as a large pocket in D5 surrounding core gp41 residues. Kinetic analysis of D5 mutants with perturbed D5-gp41 interactions suggests that D5 persistence at the fusion intermediate is crucial for neutralization. Thus, our data validate the gp41 N-peptide trimer fusion intermediate as a target for neutralizing antibodies and provide a template for identification of more potent and broadly neutralizing molecules.

About this Structure

2CMR is a Single protein structure of sequence from Homo sapiens and Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

Structural basis for HIV-1 neutralization by a gp41 fusion intermediate-directed antibody., Luftig MA, Mattu M, Di Giovine P, Geleziunas R, Hrin R, Barbato G, Bianchi E, Miller MD, Pessi A, Carfi A, Nat Struct Mol Biol. 2006 Aug;13(8):740-7. Epub 2006 Jul 23. PMID:16862157 Page seeded by OCA on Sat May 3 22:31:41 2008

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