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2cmz

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[[Image:2cmz.gif|left|200px]]
[[Image:2cmz.gif|left|200px]]
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{{Structure
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|PDB= 2cmz |SIZE=350|CAPTION= <scene name='initialview01'>2cmz</scene>, resolution 2.40&Aring;
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The line below this paragraph, containing "STRUCTURE_2cmz", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Ca+Binding+Site+For+Chain+C'>AC1</scene>
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PE4:2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL'>PE4</scene>
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{{STRUCTURE_2cmz| PDB=2cmz | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cmz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cmz OCA], [http://www.ebi.ac.uk/pdbsum/2cmz PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2cmz RCSB]</span>
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'''CRYSTAL STRUCTURE OF VSV-INDIANA (MUDD-SUMMERS STRAIN) GLYCOPROTEIN UNDER ITS ACIDIC CONFORMATION'''
'''CRYSTAL STRUCTURE OF VSV-INDIANA (MUDD-SUMMERS STRAIN) GLYCOPROTEIN UNDER ITS ACIDIC CONFORMATION'''
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[[Category: Bressanelli, S.]]
[[Category: Bressanelli, S.]]
[[Category: Roche, S.]]
[[Category: Roche, S.]]
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[[Category: envelope protein]]
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[[Category: Envelope protein]]
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[[Category: glycoprotein]]
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[[Category: Glycoprotein]]
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[[Category: lipoprotein]]
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[[Category: Lipoprotein]]
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[[Category: membrane]]
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[[Category: Membrane]]
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[[Category: membrane protein]]
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[[Category: Membrane protein]]
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[[Category: transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 22:32:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:23:47 2008''
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Revision as of 19:32, 3 May 2008

Image:2cmz.gif

Template:STRUCTURE 2cmz

CRYSTAL STRUCTURE OF VSV-INDIANA (MUDD-SUMMERS STRAIN) GLYCOPROTEIN UNDER ITS ACIDIC CONFORMATION


Overview

The vesicular stomatitis virus has an atypical membrane fusion glycoprotein (G) exhibiting a pH-dependent equilibrium between two forms at the virus surface. Membrane fusion is triggered during the transition from the high- to low-pH form. The structure of G in its low-pH form shows the classic hairpin conformation observed in all other fusion proteins in their postfusion conformation, in spite of a novel fold combining features of fusion proteins from classes I and II. The structure provides a framework for understanding the reversibility of the G conformational change. Unexpectedly, G is homologous to gB of herpesviruses, which raises important questions on viral evolution.

About this Structure

2CMZ is a Single protein structure of sequence from Vesicular stomatitis indiana virus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the low-pH form of the vesicular stomatitis virus glycoprotein G., Roche S, Bressanelli S, Rey FA, Gaudin Y, Science. 2006 Jul 14;313(5784):187-91. PMID:16840692 Page seeded by OCA on Sat May 3 22:32:51 2008

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