2cn2

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[[Image:2cn2.gif|left|200px]]
[[Image:2cn2.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2cn2 |SIZE=350|CAPTION= <scene name='initialview01'>2cn2</scene>, resolution 2.10&Aring;
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The line below this paragraph, containing "STRUCTURE_2cn2", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Cd+Binding+Site+For+Chain+B'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Xyloglucan-specific_endo-beta-1,4-glucanase Xyloglucan-specific endo-beta-1,4-glucanase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.151 3.2.1.151] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_2cn2| PDB=2cn2 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cn2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cn2 OCA], [http://www.ebi.ac.uk/pdbsum/2cn2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2cn2 RCSB]</span>
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}}
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'''CRYSTAL STRUCTURES OF CLOSTRIDIUM THERMOCELLUM XYLOGLUCANASE'''
'''CRYSTAL STRUCTURES OF CLOSTRIDIUM THERMOCELLUM XYLOGLUCANASE'''
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[[Category: Prates, J A.M.]]
[[Category: Prates, J A.M.]]
[[Category: Taylor, E J.]]
[[Category: Taylor, E J.]]
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[[Category: gh74 family]]
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[[Category: Gh74 family]]
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[[Category: glycosylhydrolase]]
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[[Category: Glycosylhydrolase]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: xyloglucanase]]
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[[Category: Xyloglucanase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 22:33:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:23:51 2008''
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Revision as of 19:33, 3 May 2008

Image:2cn2.gif

Template:STRUCTURE 2cn2

CRYSTAL STRUCTURES OF CLOSTRIDIUM THERMOCELLUM XYLOGLUCANASE


Overview

The enzymatic degradation of the plant cell wall is central both to the natural carbon cycle and, increasingly, to environmentally friendly routes to biomass conversion, including the production of biofuels. The plant cell wall is a complex composite of cellulose microfibrils embedded in diverse polysaccharides collectively termed hemicelluloses. Xyloglucan is one such polysaccharide whose hydrolysis is catalyzed by diverse xyloglucanases. Here we present the structure of the Clostridium thermocellum xyloglucanase Xgh74A in both apo and ligand-complexed forms. The structures, in combination with mutagenesis data on the catalytic residues and the kinetics and specificity of xyloglucan hydrolysis reveal a complex subsite specificity accommodating seventeen monosaccharide moieties of the multibranched substrate in an open substrate binding terrain.

About this Structure

2CN2 is a Single protein structure of sequence from Clostridium thermocellum. Full crystallographic information is available from OCA.

Reference

Crystal structures of Clostridium thermocellum xyloglucanase, XGH74A, reveal the structural basis for xyloglucan recognition and degradation., Martinez-Fleites C, Guerreiro CI, Baumann MJ, Taylor EJ, Prates JA, Ferreira LM, Fontes CM, Brumer H, Davies GJ, J Biol Chem. 2006 Aug 25;281(34):24922-33. Epub 2006 Jun 13. PMID:16772298 Page seeded by OCA on Sat May 3 22:33:15 2008

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