2gal
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(New page: 200px<br /> <applet load="2gal" size="450" color="white" frame="true" align="right" spinBox="true" caption="2gal, resolution 2.00Å" /> '''CRYSTAL STRUCTURE O...)
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Revision as of 20:10, 12 November 2007
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CRYSTAL STRUCTURE OF HUMAN GALECTIN-7 IN COMPLEX WITH GALACTOSE
Overview
Knowledge about carbohydrate recognition domains of galectins, formerly, known as S-type animal lectins, is important in understanding their, role(s) in cell-cell interactions. Here we report the crystal structure of, human galectin-7 (hGal-7), in free form and in the presence of galactose, galactosamine, lactose, and N-acetyl-lactosamine at high resolution. This, is the first structure of a galectin determined in both free and, carbohydrate-bound forms. The structure shows a fold similar to that of, the prototype galectins -1 and -2, but has greater similarity to a related, galectin molecule, Gal-10. Even though the carbohydrate-binding residues, are conserved, there are significant changes in this pocket due to, shortening of a loop structure. The monomeric hGal-7 molecule exists as a, dimer in the crystals, but adopts a packing arrangement considerably, different from that of Gal-1 and Gal-2, which has implications for, carbohydrate recognition.
About this Structure
2GAL is a Single protein structure of sequence from Homo sapiens with GAL as ligand. Full crystallographic information is available from OCA.
Reference
Structural basis for the recognition of carbohydrates by human galectin-7., Leonidas DD, Vatzaki EH, Vorum H, Celis JE, Madsen P, Acharya KR, Biochemistry. 1998 Oct 6;37(40):13930-40. PMID:9760227
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