2czt

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[[Image:2czt.gif|left|200px]]
[[Image:2czt.gif|left|200px]]
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{{Structure
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|PDB= 2czt |SIZE=350|CAPTION= <scene name='initialview01'>2czt</scene>, resolution 2.00&Aring;
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The line below this paragraph, containing "STRUCTURE_2czt", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-D_synthase Prostaglandin-D synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.99.2 5.3.99.2] </span>
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{{STRUCTURE_2czt| PDB=2czt | SCENE= }}
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|RELATEDENTRY=[[2czu|2CZU]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2czt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2czt OCA], [http://www.ebi.ac.uk/pdbsum/2czt PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2czt RCSB]</span>
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'''lipocalin-type prostaglandin D synthase'''
'''lipocalin-type prostaglandin D synthase'''
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[[Category: Urade, Y.]]
[[Category: Urade, Y.]]
[[Category: Yamamoto, M.]]
[[Category: Yamamoto, M.]]
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[[Category: c2221 native]]
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[[Category: C2221 native]]
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[[Category: lipocalin]]
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[[Category: Lipocalin]]
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[[Category: riken structural genomics/proteomics initiative]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: rsgi]]
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[[Category: Rsgi]]
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[[Category: structural genomic]]
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[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 23:25:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:28:25 2008''
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Revision as of 20:25, 3 May 2008

Image:2czt.gif

Template:STRUCTURE 2czt

lipocalin-type prostaglandin D synthase


Overview

Lipocalin-type prostaglandin D synthase is the key enzyme for the production of prostaglandin D(2), a potent endogenous somnogen, in the brain. We cloned, produced, and crystallized the native enzyme and selenomethionyl Cys(65)Ala mutants of the recombinant mouse protein by the hanging drop vapor-diffusion method with both malonate and citrate as precipitants. The native crystals obtained with malonate belong to orthorhombic space group P2(1)2(1)2(1) with lattice constants a = 46.2, b = 66.8, and c = 105.3 A. The selenomethionyl crystals obtained with citrate belong to orthorhombic space group C222(1) with lattice constants a = 45.5, b = 66.8, and c = 104.5 A. The native crystals diffracted beyond 2.1 A resolution.

About this Structure

2CZT is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Cloning, expression, crystallization, and preliminary X-ray analysis of recombinant mouse lipocalin-type prostaglandin D synthase, a somnogen-producing enzyme., Irikura D, Kumasaka T, Yamamoto M, Ago H, Miyano M, Kubata KB, Sakai H, Hayaishi O, Urade Y, J Biochem. 2003 Jan;133(1):29-32. PMID:12761195 Page seeded by OCA on Sat May 3 23:25:52 2008

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