2gmv

From Proteopedia

(Difference between revisions)
Jump to: navigation, search

OCA (Talk | contribs)
(New page: 200px<br /> <applet load="2gmv" size="450" color="white" frame="true" align="right" spinBox="true" caption="2gmv, resolution 2.30&Aring;" /> '''PEPCK complex with ...)
Next diff →

Revision as of 20:13, 12 November 2007

Image:2gmv.gif

2gmv, resolution 2.30Å

Drag the structure with the mouse to rotate

PEPCK complex with a GTP-competitive inhibitor

Contents

Overview

New modifications on the C-8 4-aminobenzyl unit of the previously reported, 3-alkyl-1,8-dibenzylxanthine inhibitors of cPEPCK are presented. The most, active compound reported here is the, 5-chloro-1,3-dimethyl-1H-pyrazole-4-sulfonic acid amide derivative 2 with, an IC(50) of 0.29+/-0.08 microM. An X-ray analysis of a heteroaromatic, sulfonamide is presented showing a new pi-pi interaction.

Disease

Known disease associated with this structure: Hypoglycemia due to PCK1 deficiency (1) OMIM:[261680]

About this Structure

2GMV is a Single protein structure of sequence from Homo sapiens with MN, PEP and UN8 as ligands. Active as Phosphoenolpyruvate carboxykinase (GTP), with EC number 4.1.1.32 Full crystallographic information is available from OCA.

Reference

C-8 Modifications of 3-alkyl-1,8-dibenzylxanthines as inhibitors of human cytosolic phosphoenolpyruvate carboxykinase., Pietranico SL, Foley LH, Huby N, Yun W, Dunten P, Vermeulen J, Wang P, Toth K, Ramsey G, Gubler ML, Wertheimer SJ, Bioorg Med Chem Lett. 2007 Jul 15;17(14):3835-9. Epub 2007 May 22. PMID:17532214

Page seeded by OCA on Mon Nov 12 22:20:09 2007

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2gmv"
Personal tools