2d2a

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2d2a.gif|left|200px]]
[[Image:2d2a.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2d2a |SIZE=350|CAPTION= <scene name='initialview01'>2d2a</scene>, resolution 2.70&Aring;
+
The line below this paragraph, containing "STRUCTURE_2d2a", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND=
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2d2a| PDB=2d2a | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2d2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d2a OCA], [http://www.ebi.ac.uk/pdbsum/2d2a PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2d2a RCSB]</span>
+
-
}}
+
'''Crystal Structure of Escherichia coli SufA Involved in Biosynthesis of Iron-sulfur Clusters'''
'''Crystal Structure of Escherichia coli SufA Involved in Biosynthesis of Iron-sulfur Clusters'''
Line 31: Line 28:
[[Category: Takahashi, Y.]]
[[Category: Takahashi, Y.]]
[[Category: Wada, K.]]
[[Category: Wada, K.]]
-
[[Category: iron]]
+
[[Category: Iron]]
-
[[Category: iron-sulfur cluster]]
+
[[Category: Iron-sulfur cluster]]
-
[[Category: isca]]
+
[[Category: Isca]]
-
[[Category: suf]]
+
[[Category: Suf]]
-
[[Category: sufa]]
+
[[Category: Sufa]]
-
[[Category: yadr]]
+
[[Category: Yadr]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 23:34:13 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:29:25 2008''
+

Revision as of 20:34, 3 May 2008

Image:2d2a.gif

Template:STRUCTURE 2d2a

Crystal Structure of Escherichia coli SufA Involved in Biosynthesis of Iron-sulfur Clusters


Overview

IscA and SufA are paralogous proteins that play crucial roles in the biosynthesis of Fe-S clusters, perhaps through a mechanism involving transient Fe-S cluster formation. We have determined the crystal structure of E. coli SufA at 2.7A resolution. SufA exists as a homodimer, in contrast to the tetrameric organization of IscA. Furthermore, a C-terminal segment containing two essential cysteine residues (Cys-Gly-Cys), which is disordered in the IscA structure, is clearly visible in one molecule (the alpha1 subunit) of the SufA homodimer. Although this segment is disordered in the other molecule (the alpha2 subunit), computer modeling of this segment based on the well-defined conformation of alpha1 subunit suggests that the four cysteine residues (Cys114 and Cys116 in each subunit) in the Cys-Gly-Cys motif are positioned in close proximity at the dimer interface. The arrangement of these cysteines together with the nearby Glu118 in SufA dimer may allow coordination of an Fe-S cluster and/or an Fe atom.

About this Structure

2D2A is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of Escherichia coli SufA involved in biosynthesis of iron-sulfur clusters: implications for a functional dimer., Wada K, Hasegawa Y, Gong Z, Minami Y, Fukuyama K, Takahashi Y, FEBS Lett. 2005 Dec 5;579(29):6543-8. Epub 2005 Nov 15. PMID:16298366 Page seeded by OCA on Sat May 3 23:34:13 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2d2a"
Personal tools