2d46
From Proteopedia
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[[Image:2d46.gif|left|200px]] | [[Image:2d46.gif|left|200px]] | ||
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| - | + | {{STRUCTURE_2d46| PDB=2d46 | SCENE= }} | |
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'''Solution Structure of the Human Beta4a-A Domain''' | '''Solution Structure of the Human Beta4a-A Domain''' | ||
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[[Category: Rithner, C D.]] | [[Category: Rithner, C D.]] | ||
[[Category: Vendel, A C.]] | [[Category: Vendel, A C.]] | ||
| - | [[Category: | + | [[Category: Alternative spliving]] |
| - | [[Category: | + | [[Category: Beta4a subunit]] |
| - | [[Category: | + | [[Category: Ca2+ channel]] |
| - | [[Category: | + | [[Category: Membrane-associated guanylate-kinase]] |
| - | [[Category: | + | [[Category: Nuclear magnetic resonance]] |
| - | [[Category: | + | [[Category: Protein structure]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 23:40:17 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 20:40, 3 May 2008
Solution Structure of the Human Beta4a-A Domain
Contents |
Overview
Ca2+ channel beta subunits regulate trafficking and gating (opening and closing) of voltage-dependent Ca2+ channel alpha1 subunits. Based on primary sequence comparisons, they are thought to be modular structures composed of five domains (A-E) that are related to the large family of membrane associated guanylate-kinase (MAGUK) proteins. The crystal structures of the beta subunit core, B-D, domains have recently been reported; however, very little is known about the structures of the A and E domains. The N-terminal A domain is a hypervariable region that differs among the four subtypes of Ca2+ channel beta subunits (beta1-beta4). Furthermore, this domain undergoes alternative splicing to create multiple N-terminal structures within a given gene class that have distinct effects on gating. We have solved the solution structure of the A domain of the human beta4a subunit, a splice variant that we have shown previously to have alpha1 subunit subtype-specific effects on Ca2+ channel trafficking and gating.
Disease
Known disease associated with this structure: Epilepsy, generalized idiopathic OMIM:[601949], Epilepsy, juvenile myoclonic OMIM:[601949], Episodic ataxia, type 5 OMIM:[601949]
About this Structure
2D46 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Solution structure of the N-terminal A domain of the human voltage-gated Ca2+channel beta4a subunit., Vendel AC, Rithner CD, Lyons BA, Horne WA, Protein Sci. 2006 Feb;15(2):378-83. Epub 2005 Dec 29. PMID:16385006 Page seeded by OCA on Sat May 3 23:40:17 2008
