2d47

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[[Image:2d47.gif|left|200px]]
[[Image:2d47.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2d47 |SIZE=350|CAPTION= <scene name='initialview01'>2d47</scene>, resolution 2.000&Aring;
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The line below this paragraph, containing "STRUCTURE_2d47", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=SPM:SPERMINE'>SPM</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|DOMAIN=
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{{STRUCTURE_2d47| PDB=2d47 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2d47 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d47 OCA], [http://www.ebi.ac.uk/pdbsum/2d47 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2d47 RCSB]</span>
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}}
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'''MOLECULAR STRUCTURE OF A COMPLETE TURN OF A-DNA'''
'''MOLECULAR STRUCTURE OF A COMPLETE TURN OF A-DNA'''
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==About this Structure==
==About this Structure==
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2D47 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D47 OCA].
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D47 OCA].
==Reference==
==Reference==
Molecular structure of a complete turn of A-DNA., Verdaguer N, Aymami J, Fernandez-Forner D, Fita I, Coll M, Huynh-Dinh T, Igolen J, Subirana JA, J Mol Biol. 1991 Sep 20;221(2):623-35. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1920437 1920437]
Molecular structure of a complete turn of A-DNA., Verdaguer N, Aymami J, Fernandez-Forner D, Fita I, Coll M, Huynh-Dinh T, Igolen J, Subirana JA, J Mol Biol. 1991 Sep 20;221(2):623-35. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1920437 1920437]
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[[Category: Protein complex]]
 
[[Category: Aymami, J.]]
[[Category: Aymami, J.]]
[[Category: Coll, M.]]
[[Category: Coll, M.]]
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[[Category: Subirana, J A.]]
[[Category: Subirana, J A.]]
[[Category: Verdaguer, N.]]
[[Category: Verdaguer, N.]]
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[[Category: a-dna]]
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[[Category: A-dna]]
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[[Category: double helix]]
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[[Category: Double helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 23:40:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:30:05 2008''
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Revision as of 20:40, 3 May 2008

Image:2d47.gif

Template:STRUCTURE 2d47

MOLECULAR STRUCTURE OF A COMPLETE TURN OF A-DNA


Overview

We have determined the crystal structure of the dodecamer d(CCCCCGCGGGGG), showing for the first time a complete turn of A-DNA. It has average structural parameters similar to those determined in fibres. Nevertheless it shows a considerable local variation in structure which is in part associated with the presence of a bound spermine molecule. We conclude that the local DNA conformation does not only depend on the base sequence, but may be strongly modified upon interaction with other molecules. In particular, the CpG sequence, which is found in hypersensitive regions of the genome, appears to be able to easily change its conformation under external influences.

About this Structure

Full crystallographic information is available from OCA.

Reference

Molecular structure of a complete turn of A-DNA., Verdaguer N, Aymami J, Fernandez-Forner D, Fita I, Coll M, Huynh-Dinh T, Igolen J, Subirana JA, J Mol Biol. 1991 Sep 20;221(2):623-35. PMID:1920437 Page seeded by OCA on Sat May 3 23:40:34 2008

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