2d4r
From Proteopedia
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'''Crystal structure of TTHA0849 from Thermus thermophilus HB8''' | '''Crystal structure of TTHA0849 from Thermus thermophilus HB8''' | ||
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]] | [[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]] | ||
[[Category: Shibata, N.]] | [[Category: Shibata, N.]] | ||
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| - | [[Category: | + | [[Category: Rsgi]] |
| - | [[Category: | + | [[Category: Start domain]] |
| - | [[Category: | + | [[Category: Structural genomic]] |
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Revision as of 20:42, 3 May 2008
Crystal structure of TTHA0849 from Thermus thermophilus HB8
Overview
The crystal structure of a conserved hypothetical protein, TTHA0849 from Thermus thermophilus HB8, has been determined at 2.4 A resolution as a part of a structural and functional genomics project on T. thermophilus HB8. The main-chain folding shows a compact alpha+beta motif, forming a hydrophobic cavity in the molecule. A structural similarity search reveals that it resembles those steroidogenic acute regulatory proteins that contain the lipid-transfer (START) domain, even though TTHA0849 shows comparatively weak sequence identity to polyketide cyclases. However, the size of the ligand-binding cavity is distinctly smaller than other START domain-containing proteins, suggesting that it catalyses the transfer of smaller ligand molecules.
About this Structure
2D4R is a Single protein structure of sequence from Thermus thermophilus. Full crystallographic information is available from OCA.
Reference
Structure of a conserved hypothetical protein, TTHA0849 from Thermus thermophilus HB8, at 2.4 A resolution: a putative member of the StAR-related lipid-transfer (START) domain superfamily., Nakabayashi M, Shibata N, Komori H, Ueda Y, Iino H, Ebihara A, Kuramitsu S, Higuchi Y, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Dec 1;61(Pt, 12):1027-31. Epub 2005 Nov 5. PMID:16511226 Page seeded by OCA on Sat May 3 23:42:19 2008
