2d5i

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[[Image:2d5i.gif|left|200px]]
[[Image:2d5i.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2d5i |SIZE=350|CAPTION= <scene name='initialview01'>2d5i</scene>, resolution 2.20&Aring;
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The line below this paragraph, containing "STRUCTURE_2d5i", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Azobenzene_reductase Azobenzene reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.7.1.6 1.7.1.6] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_2d5i| PDB=2d5i | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2d5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d5i OCA], [http://www.ebi.ac.uk/pdbsum/2d5i PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2d5i RCSB]</span>
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'''The crystal structure of AzoR (Azo Reductase) from Escherichia coli'''
'''The crystal structure of AzoR (Azo Reductase) from Escherichia coli'''
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[[Category: Ito, K.]]
[[Category: Ito, K.]]
[[Category: Tanokura, M.]]
[[Category: Tanokura, M.]]
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[[Category: azo reductase]]
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[[Category: Azo reductase]]
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[[Category: oxidoreductase]]
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[[Category: Oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 23:44:37 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:30:36 2008''
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Revision as of 20:44, 3 May 2008

Image:2d5i.gif

Template:STRUCTURE 2d5i

The crystal structure of AzoR (Azo Reductase) from Escherichia coli


Overview

The crystal structure of AzoR (azoreductase) has been determined in complex with FMN for two different crystal forms at 1.8 and 2.2 A resolution. AzoR is an oxidoreductase isolated from Escherichia coli as a protein responsible for the degradation of azo compounds. This enzyme is an FMN-dependent NADH-azoreductase and catalyzes the reductive cleavage of azo groups by a ping-pong mechanism. The structure suggests that AzoR acts in a homodimeric state forming the two identical catalytic sites to which both monomers contribute. The structure revealed that each monomer of AzoR has a flavodoxin-like structure, without the explicit overall amino acid sequence homology. Superposition of the structures from the two different crystal forms revealed the conformational change and suggested a mechanism for accommodating substrates of different size. Furthermore, comparison of the active site structure with that of NQO1 complexed with substrates provides clues to the possible substrate-binding mechanism of AzoR.

About this Structure

2D5I is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of AzoR from Escherichia coli. An oxidereductase conserved in microorganisms., Ito K, Nakanishi M, Lee WC, Sasaki H, Zenno S, Saigo K, Kitade Y, Tanokura M, J Biol Chem. 2006 Jul 21;281(29):20567-76. Epub 2006 May 9. PMID:16684776 Page seeded by OCA on Sat May 3 23:44:37 2008

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