2d5v

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[[Image:2d5v.gif|left|200px]]
[[Image:2d5v.gif|left|200px]]
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{{Structure
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|PDB= 2d5v |SIZE=350|CAPTION= <scene name='initialview01'>2d5v</scene>, resolution 2.0&Aring;
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The line below this paragraph, containing "STRUCTURE_2d5v", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE=
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|DOMAIN=
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{{STRUCTURE_2d5v| PDB=2d5v | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2d5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d5v OCA], [http://www.ebi.ac.uk/pdbsum/2d5v PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2d5v RCSB]</span>
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'''Crystal structure of HNF-6alpha DNA-binding domain in complex with the TTR promoter'''
'''Crystal structure of HNF-6alpha DNA-binding domain in complex with the TTR promoter'''
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[[Category: Watanabe, N.]]
[[Category: Watanabe, N.]]
[[Category: Yao, M.]]
[[Category: Yao, M.]]
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[[Category: transcription factor]]
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[[Category: Transcription factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 23:45:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:30:41 2008''
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Revision as of 20:45, 3 May 2008

Image:2d5v.gif

Template:STRUCTURE 2d5v

Crystal structure of HNF-6alpha DNA-binding domain in complex with the TTR promoter


Overview

Hepatocyte nuclear factor-6 (HNF-6), a liver-enriched transcription factor, controls the development of various tissues, such as the pancreas and liver, and regulates the expression of several hepatic genes. This protein belongs to the ONECUT class of homeodomain proteins and contains a bipartite DNA-binding domain composed of a single cut domain and a characteristic homeodomain. This transcription factor has two distinct modes of DNA binding and transcriptional activation that use different coactivators depending on the target gene. The crystal structure of the bipartite DNA-binding domain of HNF-6alpha complexed with the HNF-6-binding site of the TTR promoter revealed the DNA recognition mechanism of this protein. Comparing our structure with the DNA-free structure of HNF-6 or the structure of Oct-1, we discuss characteristic features associated with DNA binding and the structural basis for the dual mode of action of this protein, and we suggest a strategy for variability of transcriptional activation of the target gene.

About this Structure

2D5V is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

DNA recognition mechanism of the ONECUT homeodomain of transcription factor HNF-6., Iyaguchi D, Yao M, Watanabe N, Nishihira J, Tanaka I, Structure. 2007 Jan;15(1):75-83. PMID:17223534 Page seeded by OCA on Sat May 3 23:45:18 2008

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