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spinqualitylabelsall models 2gxb, resolution 2.25Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Crystal Structure of The Za Domain bound to Z-RNA

Contents 1 Overview 2 Disease 3 About this Structure 4 Reference

Overview

The A form RNA double helix can be transformed to a left-handed helix, called Z-RNA. Currently, little is known about the detailed structural, features of Z-RNA or its involvement in cellular processes. The discovery, that certain interferon-response proteins have domains that can stabilize, Z-RNA as well as Z-DNA opens the way for the study of Z-RNA. Here, we, present the 2.25 A crystal structure of the Zalpha domain of the, RNA-editing enzyme ADAR1 (double-stranded RNA adenosine deaminase), complexed to a dUr(CG)(3) duplex RNA. The Z-RNA helix is associated with a, unique solvent pattern that distinguishes it from the otherwise similar, conformation of Z-DNA. Based on the structure, we propose a model, suggesting how differences in solvation lead to two types of Z-RNA, structures. The interaction of Zalpha with Z-RNA demonstrates how the, interferon-induced isoform of ADAR1 could be targeted toward selected, dsRNAs containing purine-pyrimidine repeats, possibly of viral origin.

Disease

Known diseases associated with this structure: Dyschromatosis symmetrica hereditaria OMIM:[601059]

About this Structure

2GXB is a Single protein structure of sequence from Homo sapiens with NA as ligand. Full crystallographic information is available from OCA.

Reference

A Left-Handed RNA Double Helix Bound by the Zalpha Domain of the RNA-Editing Enzyme ADAR1., Placido D, Brown BA 2nd, Lowenhaupt K, Rich A, Athanasiadis A, Structure. 2007 Apr;15(4):395-404. PMID:17437712

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