2h32

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Revision as of 20:19, 12 November 2007

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spinqualitylabelsall models 2h32, resolution 2.70Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Crystal structure of the pre-B cell receptor

Contents 1 Overview 2 Disease 3 About this Structure 4 Reference

Overview

The pre-B cell receptor (pre-BCR) serves as a checkpoint in B cell, development. In the 2.7 angstrom structure of a human pre-BCR Fab-like, fragment, consisting of an antibody heavy chain (HC) paired with the, surrogate light chain, the "unique regions" of VpreB and lambda5 replace, the complementarity-determining region 3 (CDR3) loop of an antibody light, chain and appear to "probe" the HC CDR3, potentially influencing the, selection of the antibody repertoire. Biochemical analysis indicates that, the pre-BCR is impaired in its ability to recognize antigen, which, together with electron microscopic visualization of a pre-BCR dimer, suggests ligand-independent oligomerization as the likely signaling, mechanism.

Disease

Known diseases associated with this structure: Agammaglobulinemia, autosomal recessive OMIM:[146770]

About this Structure

2H32 is a Protein complex structure of sequences from Homo sapiens with ZN as ligand. Full crystallographic information is available from OCA.

Reference

Structural insight into pre-B cell receptor function., Bankovich AJ, Raunser S, Juo ZS, Walz T, Davis MM, Garcia KC, Science. 2007 Apr 13;316(5822):291-4. PMID:17431183

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