2dpk
From Proteopedia
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[[Image:2dpk.gif|left|200px]] | [[Image:2dpk.gif|left|200px]] | ||
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'''The Crystal Structure of the Primary Ca2+ Sensor of the Na+/Ca2+ Exchanger''' | '''The Crystal Structure of the Primary Ca2+ Sensor of the Na+/Ca2+ Exchanger''' | ||
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[[Category: Abramson, J.]] | [[Category: Abramson, J.]] | ||
[[Category: Sawaya, M.]] | [[Category: Sawaya, M.]] | ||
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| - | [[Category: | + | [[Category: Calcium sensory domain]] |
| - | [[Category: | + | [[Category: Cis-proline]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 00:55:08 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 21:55, 3 May 2008
The Crystal Structure of the Primary Ca2+ Sensor of the Na+/Ca2+ Exchanger
Overview
The Na+/Ca2+ exchanger is a plasma membrane protein that regulates intracellular Ca2+ levels in cardiac myocytes. Transport activity is governed by Ca2+, and the primary Ca2+ sensor (CBD1) is located in a large cytoplasmic loop connecting two transmembrane helices. The binding of Ca2+ to the CBD1 sensory domain results in conformational changes that stimulate the exchanger to extrude Ca2+. Here, we present a crystal structure of CBD1 at 2.5A resolution, which reveals a novel Ca2+ binding site consisting of four Ca2+ ions arranged in a tight planar cluster. This intricate coordination pattern for a Ca2+ binding cluster is indicative of a highly sensitive Ca2+ sensor and may represent a general platform for Ca2+ sensing.
About this Structure
2DPK is a Single protein structure of sequence from Canis lupus familiaris. Full crystallographic information is available from OCA.
Reference
The crystal structure of the primary Ca2+ sensor of the Na+/Ca2+ exchanger reveals a novel Ca2+ binding motif., Nicoll DA, Sawaya MR, Kwon S, Cascio D, Philipson KD, Abramson J, J Biol Chem. 2006 Aug 4;281(31):21577-81. Epub 2006 Jun 14. PMID:16774926 Page seeded by OCA on Sun May 4 00:55:08 2008
