2dpx

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[[Image:2dpx.gif|left|200px]]
[[Image:2dpx.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2dpx |SIZE=350|CAPTION= <scene name='initialview01'>2dpx</scene>, resolution 1.80&Aring;
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The line below this paragraph, containing "STRUCTURE_2dpx", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=GDP:GUANOSINE-5&#39;-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Small_monomeric_GTPase Small monomeric GTPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.5.2 3.6.5.2] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= RRAD, RAD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_2dpx| PDB=2dpx | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dpx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dpx OCA], [http://www.ebi.ac.uk/pdbsum/2dpx PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2dpx RCSB]</span>
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}}
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'''Crystal Structure of human Rad GTPase'''
'''Crystal Structure of human Rad GTPase'''
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[[Category: Sakurai, S.]]
[[Category: Sakurai, S.]]
[[Category: Yanuar, A.]]
[[Category: Yanuar, A.]]
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[[Category: diabetes]]
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[[Category: Diabetes]]
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[[Category: gtpase]]
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[[Category: Gtpase]]
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[[Category: rad]]
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[[Category: Rad]]
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[[Category: rgk]]
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[[Category: Rgk]]
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[[Category: signal transduction]]
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[[Category: Signal transduction]]
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[[Category: small-g]]
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[[Category: Small-g]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 00:56:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:37:48 2008''
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Revision as of 21:56, 3 May 2008

Image:2dpx.gif

Template:STRUCTURE 2dpx

Crystal Structure of human Rad GTPase


Overview

Rad (Ras associated with diabetes) is an RGK-family small GTPase that is over-expressed in the skeletal muscle of humans with type II diabetes. Unlike other small GTPases, RGK family members including Rad lack several conserved residues in the GTPase domain. Here, we report the crystal structure of the GTPase domain of human Rad in the GDP-bound form at 1.8 A resolution. The structure revealed unexpected disordered structures of both switches I and II. We showed that the conformational flexibility of both switches is caused by non-conservative substitutions in the G2 and G3 motifs forming the switch cores together with other substitutions in the structural elements interacting with the switches. Glycine-rich sequences of the switches would also contribute to the flexibility. Switch I lacks the conserved phenylalanine that makes non-polar interactions with the guanine base in H-Ras. Instead, water-mediated hydrogen bonding interactions were observed in Rad. The GDP molecule is located at the same position as in H-Ras and adopts a similar conformation as that bound in H-Ras. This similarity seems to be endowed by the conserved hydrogen bonding interactions with the guanine base-recognition loops and the magnesium ion that has a typical octahedral coordination shell identical to that in H-Ras.

About this Structure

2DPX is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human Rad GTPase of the RGK-family., Yanuar A, Sakurai S, Kitano K, Hakoshima T, Genes Cells. 2006 Aug;11(8):961-8. PMID:16866878 Page seeded by OCA on Sun May 4 00:56:10 2008

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