2dqs

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[[Image:2dqs.jpg|left|200px]]
[[Image:2dqs.jpg|left|200px]]
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{{Structure
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|PDB= 2dqs |SIZE=350|CAPTION= <scene name='initialview01'>2dqs</scene>, resolution 2.50&Aring;
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The line below this paragraph, containing "STRUCTURE_2dqs", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PTY:PHOSPHATIDYLETHANOLAMINE'>PTY</scene>, <scene name='pdbligand=TG1:OCTANOIC+ACID+[3S-[3ALPHA,+3ABETA,+4ALPHA,+6BETA,+6ABETA,+7BETA,+8ALPHA(Z),+9BALPHA]]-6-(ACETYLOXY)-2,3,-3A,4,5,6,6A,7,8,9B-DECAHYDRO-3,3A-DIHYDROXY-3,6,9-TRIMETHYL-8-[(2-METHYL-1-OXO-2-BUTENYL)OXY]-2-OXO-4-(1-OXOBUTOXY)-AZULENO[4,5-B]FURAN-7-YL+ESTER'>TG1</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Calcium-transporting_ATPase Calcium-transporting ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.8 3.6.3.8] </span>
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|GENE=
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|DOMAIN=
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{{STRUCTURE_2dqs| PDB=2dqs | SCENE= }}
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|RELATEDENTRY=[[1su4|1SU4]], [[1iwo|1IWO]], [[1vfp|1VFP]], [[1wpe|1WPE]], [[1wpg|1WPG]], [[2agv|2AGV]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dqs OCA], [http://www.ebi.ac.uk/pdbsum/2dqs PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2dqs RCSB]</span>
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}}
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'''Crystal structure of the calcium pump with amppcp in the absence of calcium'''
'''Crystal structure of the calcium pump with amppcp in the absence of calcium'''
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[[Category: Toyoshima, C.]]
[[Category: Toyoshima, C.]]
[[Category: Tsueda, J.]]
[[Category: Tsueda, J.]]
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[[Category: amppcp]]
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[[Category: Amppcp]]
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[[Category: membrane protein]]
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[[Category: Membrane protein]]
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[[Category: p-type atpase]]
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[[Category: P-type atpase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 00:58:41 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:38:11 2008''
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Revision as of 21:58, 3 May 2008

Image:2dqs.jpg

Template:STRUCTURE 2dqs

Crystal structure of the calcium pump with amppcp in the absence of calcium


Overview

Calcium ATPase is a member of the P-type ATPases that transport ions across the membrane against a concentration gradient. Here we have solved the crystal structure of the calcium ATPase of skeletal muscle sarcoplasmic reticulum (SERCA1a) at 2.6 A resolution with two calcium ions bound in the transmembrane domain, which comprises ten alpha-helices. The two calcium ions are located side by side and are surrounded by four transmembrane helices, two of which are unwound for efficient coordination geometry. The cytoplasmic region consists of three well separated domains, with the phosphorylation site in the central catalytic domain and the adenosine-binding site on another domain. The phosphorylation domain has the same fold as haloacid dehalogenase. Comparison with a low-resolution electron density map of the enzyme in the absence of calcium and with biochemical data suggests that large domain movements take place during active transport.

About this Structure

2DQS is a Single protein structure of sequence from Oryctolagus cuniculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the calcium pump of sarcoplasmic reticulum at 2.6 A resolution., Toyoshima C, Nakasako M, Nomura H, Ogawa H, Nature. 2000 Jun 8;405(6787):647-55. PMID:10864315 Page seeded by OCA on Sun May 4 00:58:41 2008

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