2hbh
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(New page: 200px<br /> <applet load="2hbh" size="450" color="white" frame="true" align="right" spinBox="true" caption="2hbh, resolution 2.65Å" /> '''Crystal structure o...)
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Revision as of 20:23, 12 November 2007
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Crystal structure of Vitamin D nuclear receptor ligand binding domain bound to a locked side-chain analog of calcitriol and SRC-1 peptide
Overview
The crystal structures of vitamin D nuclear receptor (VDR) have revealed, that all compounds are anchored by the same residues to the ligand binding, pocket (LBP). Based on this observation, a synthetic analog with a locked, side chain (21-nor-calcitriol-20(22),23-diyne) has been synthesized in, order to gain in entropy energy with a predefined active side chain, conformation. The crystal structure of VDR LBD bound to this locked side, chain analogue while confirming the docking provides a structural basis, for the activity of this compound.
About this Structure
2HBH is a Protein complex structure of sequences from Danio rerio with XE4 as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structure of the vitamin D nuclear receptor ligand binding domain in complex with a locked side chain analog of calcitriol., Rochel N, Hourai S, Perez-Garcia X, Rumbo A, Mourino A, Moras D, Arch Biochem Biophys. 2007 Apr 15;460(2):172-6. Epub 2007 Feb 20. PMID:17346665
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