2hck

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(New page: 200px<br /> <applet load="2hck" size="450" color="white" frame="true" align="right" spinBox="true" caption="2hck, resolution 3.0&Aring;" /> '''SRC FAMILY KINASE HC...)
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Revision as of 20:23, 12 November 2007

Image:2hck.gif

2hck, resolution 3.0Å

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SRC FAMILY KINASE HCK-QUERCETIN COMPLEX

Overview

The crystal structure of the haematopoietic cell kinase Hck has been, determined at 2.6/2.9 A resolution. Inhibition of enzymatic activity is a, consequence of intramolecular interactions of the enzyme's Src-homology, domains SH2 and SH3, with concomitant displacement of elements of the, catalytic domain. The conformation of the active site has similarities, with that of inactive cyclin-dependent protein kinases.

About this Structure

2HCK is a Single protein structure of sequence from Homo sapiens with CA and QUE as ligands. The following page contains interesting information on the relation of 2HCK with [Src Tyrosine Kinase]. Active as Transferase, with EC number and 2.7.10.2 2.7.10.1 and 2.7.10.2 Full crystallographic information is available from OCA.

Reference

Crystal structure of the Src family tyrosine kinase Hck., Sicheri F, Moarefi I, Kuriyan J, Nature. 1997 Feb 13;385(6617):602-9. PMID:9024658

Page seeded by OCA on Mon Nov 12 22:30:20 2007

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