2dx5

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[[Image:2dx5.gif|left|200px]]
[[Image:2dx5.gif|left|200px]]
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{{Structure
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{{STRUCTURE_2dx5| PDB=2dx5 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dx5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dx5 OCA], [http://www.ebi.ac.uk/pdbsum/2dx5 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2dx5 RCSB]</span>
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'''The complex structure between the mouse EAP45-GLUE domain and ubiquitin'''
'''The complex structure between the mouse EAP45-GLUE domain and ubiquitin'''
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[[Category: Trambaiolo, D.]]
[[Category: Trambaiolo, D.]]
[[Category: Wakatsuki, S.]]
[[Category: Wakatsuki, S.]]
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[[Category: protein-protein complex]]
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[[Category: Protein-protein complex]]
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[[Category: ubiquitin]]
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[[Category: Ubiquitin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 01:33:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:40:48 2008''
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Revision as of 22:33, 3 May 2008

Image:2dx5.gif

Template:STRUCTURE 2dx5

The complex structure between the mouse EAP45-GLUE domain and ubiquitin


Overview

ESCRT-II, a complex that sorts ubiquitinated membrane proteins to lysosomes, localizes to endosomes through interaction between the Vps36 subunit's GLUE domain and phosphatidylinositides (PIs). In yeast, a ubiquitin (Ub)-interacting NZF domain is inserted in Vps36 GLUE, whereas its mammalian counterpart, Eap45 GLUE, lacks the NZF domain. In the Eap45 GLUE-Ub complex structure, Ub binds far from the proposed PI-binding site of Eap45 GLUE, suggesting their independent binding.

About this Structure

2DX5 is a Protein complex structure of sequences from Bos taurus and Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural basis of ubiquitin recognition by mammalian Eap45 GLUE domain., Hirano S, Suzuki N, Slagsvold T, Kawasaki M, Trambaiolo D, Kato R, Stenmark H, Wakatsuki S, Nat Struct Mol Biol. 2006 Nov;13(11):1031-2. Epub 2006 Oct 22. PMID:17057714 Page seeded by OCA on Sun May 4 01:33:21 2008

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