2dxs

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[[Image:2dxs.jpg|left|200px]]
[[Image:2dxs.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2dxs |SIZE=350|CAPTION= <scene name='initialview01'>2dxs</scene>, resolution 2.20&Aring;
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The line below this paragraph, containing "STRUCTURE_2dxs", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=JTP:N-[(13-CYCLOHEXYL-6,7-DIHYDROINDOLO[1,2-D][1,4]BENZOXAZEPIN-10-YL)CARBONYL]-2-METHYL-L-ALANINE'>JTP</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= 1B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11103 Hepatitis C virus])
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-->
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|DOMAIN=
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{{STRUCTURE_2dxs| PDB=2dxs | SCENE= }}
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|RELATEDENTRY=[[1quv|1QUV]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dxs OCA], [http://www.ebi.ac.uk/pdbsum/2dxs PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2dxs RCSB]</span>
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}}
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'''Crystal structure of HCV NS5B RNA polymerase complexed with a tetracyclic inhibitor'''
'''Crystal structure of HCV NS5B RNA polymerase complexed with a tetracyclic inhibitor'''
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[[Category: Uehara, K.]]
[[Category: Uehara, K.]]
[[Category: Watanabe, S.]]
[[Category: Watanabe, S.]]
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[[Category: hcv]]
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[[Category: Hcv]]
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[[Category: ns5b]]
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[[Category: Ns5b]]
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[[Category: rna polymerase]]
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[[Category: Rna polymerase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 01:35:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:41:02 2008''
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Revision as of 22:35, 3 May 2008

Image:2dxs.jpg

Template:STRUCTURE 2dxs

Crystal structure of HCV NS5B RNA polymerase complexed with a tetracyclic inhibitor


Overview

We report a new series of hepatitis C virus NS5B RNA polymerase inhibitors containing a conformationally constrained tetracyclic scaffold. SAR studies led to the identification of 6,7-dihydro-5H-benzo[5,6][1,4]diazepino[7,1-a]indoles (19 and 20) bearing a basic pendent group with high biochemical and cellular potencies. These compounds displayed a very small shift in cellular potency when the replicon assay was performed in the presence of human serum albumin.

About this Structure

2DXS is a Single protein structure of sequence from Hepatitis c virus. Full crystallographic information is available from OCA.

Reference

Discovery of conformationally constrained tetracyclic compounds as potent hepatitis C virus NS5B RNA polymerase inhibitors., Ikegashira K, Oka T, Hirashima S, Noji S, Yamanaka H, Hara Y, Adachi T, Tsuruha J, Doi S, Hase Y, Noguchi T, Ando I, Ogura N, Ikeda S, Hashimoto H, J Med Chem. 2006 Nov 30;49(24):6950-3. PMID:17125247 Page seeded by OCA on Sun May 4 01:35:01 2008

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OCA

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