2hfp

From Proteopedia

---

Revision as of 20:25, 12 November 2007

proteopedia linkproteopedia link

spinqualitylabelsall models 2hfp, resolution 2.000Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Crystal Structure of PPAR Gamma with N-sulfonyl-2-indole carboxamide ligands

Contents 1 Overview 2 Disease 3 About this Structure 4 Reference

Overview

The synthesis and structure-activity relationships of a novel series of, N-sulfonyl-2-indole carboxamides that bind to peroxisome, proliferator-activated receptor gamma (PPAR-gamma) are reported. Chemical, optimization of the series led to the identification of 4q (IC(50)=50 nM), as a potent binding agent of PPAR-gamma. Also reported is preliminary cell, based data suggesting the use of these compounds in the treatment of, osteoporosis.

Disease

Known diseases associated with this structure: Abdominal body fat distribution, modifier of OMIM:[601487], Diabetes mellitus, insulin-resistant, with acanthosis nigricans and hypertension OMIM:[601487], Glioblastoma, susceptibility to OMIM:[601487], Insulin resistance, severe, digenic OMIM:[601487], Lipodystrophy, familial partial OMIM:[601487], Obesity, resistance to OMIM:[601487], Obesity, severe OMIM:[601487]

About this Structure

2HFP is a Protein complex structure of sequences from Homo sapiens with NSI as ligand. Full crystallographic information is available from OCA.

Reference

Design and synthesis of novel N-sulfonyl-2-indole carboxamides as potent PPAR-gamma binding agents with potential application to the treatment of osteoporosis., Hopkins CR, O'neil SV, Laufersweiler MC, Wang Y, Pokross M, Mekel M, Evdokimov A, Walter R, Kontoyianni M, Petrey ME, Sabatakos G, Roesgen JT, Richardson E, Demuth TP Jr, Bioorg Med Chem Lett. 2006 Nov 1;16(21):5659-63. Epub 2006 Aug 21. PMID:16919947

Page seeded by OCA on Mon Nov 12 22:31:56 2007