2hha

From Proteopedia

(Difference between revisions)
Jump to: navigation, search

OCA (Talk | contribs)
(New page: 200px<br /> <applet load="2hha" size="450" color="white" frame="true" align="right" spinBox="true" caption="2hha, resolution 2.350&Aring;" /> '''The structure of D...)
Next diff →

Revision as of 20:26, 12 November 2007

Image:2hha.gif

2hha, resolution 2.350Å

Drag the structure with the mouse to rotate

The structure of DPP4 in complex with an oxadiazole inhibitor

Overview

A novel series of oxadiazole based amides have been shown to be potent, DPP-4 inhibitors. The optimized compound 43 exhibited excellent, selectivity over a variety of DPP-4 homologs.

About this Structure

2HHA is a Single protein structure of sequence from Homo sapiens with NAG, NA and 3TP as ligands. Active as Dipeptidyl-peptidase IV, with EC number 3.4.14.5 Full crystallographic information is available from OCA.

Reference

Discovery of potent, selective, and orally bioavailable oxadiazole-based dipeptidyl peptidase IV inhibitors., Xu J, Wei L, Mathvink RJ, Edmondson SD, Eiermann GJ, He H, Leone JF, Leiting B, Lyons KA, Marsilio F, Patel RA, Patel SB, Petrov A, Scapin G, Wu JK, Thornberry NA, Weber AE, Bioorg Med Chem Lett. 2006 Oct 15;16(20):5373-7. Epub 2006 Aug 17. PMID:16919457

Page seeded by OCA on Mon Nov 12 22:32:32 2007

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2hha"
Personal tools