This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2hiu
From Proteopedia
OCA (Talk | contribs)
(New page: 200px<br /> <applet load="2hiu" size="450" color="white" frame="true" align="right" spinBox="true" caption="2hiu" /> '''NMR STRUCTURE OF HUMAN INSULIN IN 20% ACETI...)
Next diff →
Revision as of 20:26, 12 November 2007
|
NMR STRUCTURE OF HUMAN INSULIN IN 20% ACETIC ACID, ZINC-FREE, 10 STRUCTURES
Contents |
Overview
We have determined the structure of a metastable disulphide isomer of, human insulin. Although not observed for proinsulin folding or, insulin-chain recombination, the isomer retains ordered secondary, structure and a compact hydrophobic core. Comparison with native insulin, reveals a global rearrangement in the orientation of A- and B-chains. One, face of the protein's surface is nevertheless in common between native and, non-native structures. This face contains receptor-binding determinants, rationalizing the partial biological activity of the isomer. Structures of, native and non-native disulphide isomers also define alternative, three-dimensional templates. Threading of insulin-like sequences provide, an experimental realization of the inverse protein-folding problem.
Disease
Known diseases associated with this structure: Diabetes mellitus, rare form OMIM:[176730], Hyperproinsulinemia, familial OMIM:[176730], MODY, one form OMIM:[176730]
About this Structure
2HIU is a Protein complex structure of sequences from Homo sapiens. This structure superseeds the now removed PDB entry 1HIU. The following page contains interesting information on the relation of 2HIU with [Insulin]. Full crystallographic information is available from OCA.
Reference
Structure of a protein in a kinetic trap., Hua QX, Gozani SN, Chance RE, Hoffmann JA, Frank BH, Weiss MA, Nat Struct Biol. 1995 Feb;2(2):129-38. PMID:7749917
Page seeded by OCA on Mon Nov 12 22:33:07 2007
