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2hiz
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(New page: 200px<br /> <applet load="2hiz" size="450" color="white" frame="true" align="right" spinBox="true" caption="2hiz, resolution 2.500Å" /> '''Crystal Structure ...)
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Revision as of 20:26, 12 November 2007
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Crystal Structure of human beta-secretase (BACE) in the presence of an inhibitor
Overview
We describe a novel series of potent inhibitors of human beta-secretase., These compounds possess the hydroxyethyl amine transition state isostere., A 2.5A crystal structure of inhibitor 32 bound to BACE is provided.
About this Structure
2HIZ is a Single protein structure of sequence from Homo sapiens with PO4 and LIJ as ligands. Active as Memapsin 2, with EC number 3.4.23.46 Full crystallographic information is available from OCA.
Reference
Design of potent inhibitors of human beta-secretase. Part 1., Freskos JN, Fobian YM, Benson TE, Bienkowski MJ, Brown DL, Emmons TL, Heintz R, Laborde A, McDonald JJ, Mischke BV, Molyneaux JM, Moon JB, Mullins PB, Bryan Prince D, Paddock DJ, Tomasselli AG, Winterrowd G, Bioorg Med Chem Lett. 2007 Jan 1;17(1):73-7. Epub 2006 Oct 4. PMID:17046251
Page seeded by OCA on Mon Nov 12 22:33:13 2007
