2hiz

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(New page: 200px<br /> <applet load="2hiz" size="450" color="white" frame="true" align="right" spinBox="true" caption="2hiz, resolution 2.500&Aring;" /> '''Crystal Structure ...)
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Revision as of 20:26, 12 November 2007

Image:2hiz.gif

2hiz, resolution 2.500Å

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Crystal Structure of human beta-secretase (BACE) in the presence of an inhibitor

Overview

We describe a novel series of potent inhibitors of human beta-secretase., These compounds possess the hydroxyethyl amine transition state isostere., A 2.5A crystal structure of inhibitor 32 bound to BACE is provided.

About this Structure

2HIZ is a Single protein structure of sequence from Homo sapiens with PO4 and LIJ as ligands. Active as Memapsin 2, with EC number 3.4.23.46 Full crystallographic information is available from OCA.

Reference

Design of potent inhibitors of human beta-secretase. Part 1., Freskos JN, Fobian YM, Benson TE, Bienkowski MJ, Brown DL, Emmons TL, Heintz R, Laborde A, McDonald JJ, Mischke BV, Molyneaux JM, Moon JB, Mullins PB, Bryan Prince D, Paddock DJ, Tomasselli AG, Winterrowd G, Bioorg Med Chem Lett. 2007 Jan 1;17(1):73-7. Epub 2006 Oct 4. PMID:17046251

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