This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2hn7
From Proteopedia
OCA (Talk | contribs)
(New page: 200px<br /> <applet load="2hn7" size="450" color="white" frame="true" align="right" spinBox="true" caption="2hn7, resolution 1.60Å" /> '''HLA-A*1101 in compl...)
Next diff →
Revision as of 20:27, 12 November 2007
|
HLA-A*1101 in complex with HBV peptide homologue
Contents |
Overview
A high-resolution structure of the human MHC-I molecule HLA-A*1101 is, presented in which it forms a complex with a sequence homologue of a, peptide that occurs naturally in hepatitis B virus DNA polymerase. The, sequence of the bound peptide is AIMPARFYPK, while that of the, corresponding natural peptide is LIMPARFYPK. The peptide does not make, efficient use of the middle E pocket for binding, which leads to a rather, superficial and exposed binding mode for the central peptide residues., Despite this, the peptide binds with high affinity (IC50 of 31 nM).
Disease
Known diseases associated with this structure: Abacavir hypersensitivity, susceptibility to OMIM:[142800], Ankylosing spondylitis, susceptibility to, 1 OMIM:[142800], Hypoproteinemia, hypercatabolic OMIM:[109700], Stevens-Johnson syndrome, susceptibility to OMIM:[142800]
About this Structure
2HN7 is a Protein complex structure of sequences from Homo sapiens with SO4 as ligand. Full crystallographic information is available from OCA.
Reference
Structure of HLA-A*1101 in complex with a hepatitis B peptide homologue., Blicher T, Kastrup JS, Pedersen LO, Buus S, Gajhede M, Acta Crystallograph Sect F Struct Biol Cryst Commun. 2006 Dec 1;62(Pt, 12):1179-84. Epub 2006 Nov 4. PMID:17142892
Page seeded by OCA on Mon Nov 12 22:34:15 2007
