2hyi
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(New page: 200px<br /> <applet load="2hyi" size="450" color="white" frame="true" align="right" spinBox="true" caption="2hyi, resolution 2.3Å" /> '''Structure of the hum...)
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Revision as of 20:31, 12 November 2007
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Structure of the human exon junction complex with a trapped DEAD-box helicase bound to RNA
Overview
In higher eukaryotes, a multiprotein exon junction complex is deposited on, spliced messenger RNAs. The complex is organized around a stable core, which serves as a binding platform for numerous factors that influence, messenger RNA function. Here, we present the crystal structure of a, tetrameric exon junction core complex containing the DEAD-box adenosine, triphosphatase (ATPase) eukaryotic initiation factor 4AIII (eIF4AIII), bound to an ATP analog, MAGOH, Y14, a fragment of MLN51, and a polyuracil, mRNA mimic. eIF4AIII interacts with the phosphate-ribose backbone of six, consecutive nucleotides and prevents part of the bound RNA from being, double stranded. The MAGOH and Y14 subunits lock eIF4AIII in a, prehydrolysis state, and activation of the ATPase probably requires only, modest conformational changes in eIF4AIII motif I.
About this Structure
2HYI is a Protein complex structure of sequences from Homo sapiens with MG and ANP as ligands. Full crystallographic information is available from OCA.
Reference
Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA., Andersen CB, Ballut L, Johansen JS, Chamieh H, Nielsen KH, Oliveira CL, Pedersen JS, Seraphin B, Le Hir H, Andersen GR, Science. 2006 Sep 29;313(5795):1968-72. Epub 2006 Aug 24. PMID:16931718
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