2eho

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2eho.jpg|left|200px]]
[[Image:2eho.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2eho |SIZE=350|CAPTION= <scene name='initialview01'>2eho</scene>, resolution 3.00&Aring;
+
The line below this paragraph, containing "STRUCTURE_2eho", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE= Psf1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), PSF2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), Psf3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2eho| PDB=2eho | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eho OCA], [http://www.ebi.ac.uk/pdbsum/2eho PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2eho RCSB]</span>
+
-
}}
+
'''Crystal structure of human GINS complex'''
'''Crystal structure of human GINS complex'''
Line 34: Line 31:
[[Category: Song, O K.]]
[[Category: Song, O K.]]
[[Category: 4-helical bundle]]
[[Category: 4-helical bundle]]
-
[[Category: hydrophobic interaction]]
+
[[Category: Hydrophobic interaction]]
-
[[Category: protein-protein complex]]
+
[[Category: Protein-protein complex]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 02:34:11 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:49:14 2008''
+

Revision as of 23:34, 3 May 2008

Image:2eho.jpg

Template:STRUCTURE 2eho

Crystal structure of human GINS complex


Contents

Overview

The GINS complex mediates the assembly of the MCM2-7 (minichromosome maintenance) complex with proteins in a replisome progression complex. The eukaryotic GINS complex is composed of Sld5, Psf1, Psf2, and Psf3, which must be assembled for cell proliferation. We determined the crystal structure of the human GINS complex: GINS forms an elliptical shape with a small central channel. The structures of Sld5 and Psf2 resemble those of Psf1 and Psf3, respectively. In addition, the N-terminal and C-terminal domains of Sld5/Psf1 are permuted in Psf2/Psf3, which suggests that the four proteins have evolved from a common ancestor. Using a structure-based mutational analysis, we identified the functionally critical surface regions of the GINS complex.

Disease

Known disease associated with this structure: Bare lymphocyte syndrome, type I, due to TAP2 deficiency OMIM:[170261], Wegener-like granulomatosis OMIM:[170261]

About this Structure

2EHO is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the human GINS complex., Choi JM, Lim HS, Kim JJ, Song OK, Cho Y, Genes Dev. 2007 Jun 1;21(11):1316-21. PMID:17545466 Page seeded by OCA on Sun May 4 02:34:11 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2eho"
Personal tools