2erf

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2erf.gif|left|200px]]
[[Image:2erf.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2erf |SIZE=350|CAPTION= <scene name='initialview01'>2erf</scene>, resolution 1.45&Aring;
+
The line below this paragraph, containing "STRUCTURE_2erf", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND=
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE= THBS1, TSP, TSP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2erf| PDB=2erf | SCENE= }}
-
|RELATEDENTRY=[[1z78|1Z78]], [[1za4|1ZA4]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2erf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2erf OCA], [http://www.ebi.ac.uk/pdbsum/2erf PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2erf RCSB]</span>
+
-
}}
+
'''Crystal Structure of the Thrombospondin-1 N-terminal Domain at 1.45A Resolution'''
'''Crystal Structure of the Thrombospondin-1 N-terminal Domain at 1.45A Resolution'''
Line 28: Line 25:
[[Category: Tan, K.]]
[[Category: Tan, K.]]
[[Category: Wang, J.]]
[[Category: Wang, J.]]
-
[[Category: hbd]]
+
[[Category: Hbd]]
-
[[Category: n-terminal tspn]]
+
[[Category: N-terminal tspn]]
-
[[Category: thrombospondin-1]]
+
[[Category: Thrombospondin-1]]
-
[[Category: tsp-1]]
+
[[Category: Tsp-1]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:01:56 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:52:50 2008''
+

Revision as of 00:01, 4 May 2008

Image:2erf.gif

Template:STRUCTURE 2erf

Crystal Structure of the Thrombospondin-1 N-terminal Domain at 1.45A Resolution


Overview

The N-terminal domain of thrombospondin-1 (TSPN-1) mediates the protein's interaction with (1) glycosaminoglycans, calreticulin, and integrins during cellular adhesion, (2) low-density lipoprotein receptor-related protein during uptake and clearance, and (3) fibrinogen during platelet aggregation. The crystal structure of TSPN-1 to 1.8 A resolution is a beta sandwich with 13 antiparallel beta strands and 1 irregular strand-like segment. Unique structural features of the N- and C-terminal regions, and the disulfide bond location, distinguish TSPN-1 from the laminin G domain and other concanavalin A-like lectins/glucanases superfamily members. The crystal structure of the complex of TSPN-1 with heparin indicates that residues R29, R42, and R77 in an extensive positively charged patch at the bottom of the domain specifically associate with the sulfate groups of heparin. The TSPN-1 structure and identified adjacent linker region provide a structural framework for the analysis of the TSPN domain of various molecules, including TSPs, NELLs, many collagens, TSPEAR, and kielin.

About this Structure

2ERF is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structures of the thrombospondin-1 N-terminal domain and its complex with a synthetic pentameric heparin., Tan K, Duquette M, Liu JH, Zhang R, Joachimiak A, Wang JH, Lawler J, Structure. 2006 Jan;14(1):33-42. PMID:16407063 Page seeded by OCA on Sun May 4 03:01:56 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2erf"
Personal tools